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- W2063516500 endingPage "308" @default.
- W2063516500 startingPage "280" @default.
- W2063516500 abstract "The Paramyxoviridae genus Henipavirus is presently represented by the type species Hendra and Nipah viruses which are both recently emerged zoonotic viral pathogens responsible for repeated outbreaks associated with high morbidity and mortality in Australia, Southeast Asia, India and Bangladesh. These enveloped viruses bind and enter host target cells through the coordinated activities of their attachment (G) and class I fusion (F) envelope glycoproteins. The henipavirus G glycoprotein interacts with host cellular B class ephrins, triggering conformational alterations in G that lead to the activation of the F glycoprotein, which facilitates the membrane fusion process. Using the recently published structures of HeV-G and NiV-G and other paramyxovirus glycoproteins, we review the features of the henipavirus envelope glycoproteins that appear essential for mediating the viral fusion process, including receptor binding, G-F interaction, F activation, with an emphasis on G and the mutations that disrupt viral infectivity. Finally, recent candidate therapeutics for henipavirus-mediated disease are summarized in light of their ability to inhibit HeV and NiV entry by targeting their G and F glycoproteins." @default.
- W2063516500 created "2016-06-24" @default.
- W2063516500 creator A5006321543 @default.
- W2063516500 creator A5009226631 @default.
- W2063516500 creator A5042543645 @default.
- W2063516500 creator A5062361189 @default.
- W2063516500 date "2012-02-13" @default.
- W2063516500 modified "2023-10-06" @default.
- W2063516500 title "Henipavirus Mediated Membrane Fusion, Virus Entry and Targeted Therapeutics" @default.
- W2063516500 cites W1207182455 @default.
- W2063516500 cites W1506487234 @default.
- W2063516500 cites W1570073947 @default.
- W2063516500 cites W1644209505 @default.
- W2063516500 cites W1850066587 @default.
- W2063516500 cites W1963944990 @default.
- W2063516500 cites W1966029727 @default.
- W2063516500 cites W1968918303 @default.
- W2063516500 cites W1969347183 @default.
- W2063516500 cites W1972940026 @default.
- W2063516500 cites W1973101424 @default.
- W2063516500 cites W1973647109 @default.
- W2063516500 cites W1974077634 @default.
- W2063516500 cites W1977356160 @default.
- W2063516500 cites W1977672771 @default.
- W2063516500 cites W1978118805 @default.
- W2063516500 cites W1978614903 @default.
- W2063516500 cites W1981344307 @default.
- W2063516500 cites W1984286626 @default.
- W2063516500 cites W1987893884 @default.
- W2063516500 cites W1988494648 @default.
- W2063516500 cites W1990922204 @default.
- W2063516500 cites W1991093481 @default.
- W2063516500 cites W1991743592 @default.
- W2063516500 cites W1992045316 @default.
- W2063516500 cites W1992187858 @default.
- W2063516500 cites W1994436536 @default.
- W2063516500 cites W1995188653 @default.
- W2063516500 cites W1997670728 @default.
- W2063516500 cites W1998386600 @default.
- W2063516500 cites W1998722777 @default.
- W2063516500 cites W1999267207 @default.
- W2063516500 cites W2002135415 @default.
- W2063516500 cites W2003829444 @default.
- W2063516500 cites W2006835046 @default.
- W2063516500 cites W2007143893 @default.
- W2063516500 cites W2010145969 @default.
- W2063516500 cites W2011937142 @default.
- W2063516500 cites W2016701198 @default.
- W2063516500 cites W2017153127 @default.
- W2063516500 cites W2018601378 @default.
- W2063516500 cites W2021540849 @default.
- W2063516500 cites W2022077785 @default.
- W2063516500 cites W2022100172 @default.
- W2063516500 cites W2023735985 @default.
- W2063516500 cites W2026547503 @default.
- W2063516500 cites W2032294909 @default.
- W2063516500 cites W2033674509 @default.
- W2063516500 cites W2039635444 @default.
- W2063516500 cites W2041805602 @default.
- W2063516500 cites W2046563809 @default.
- W2063516500 cites W2048573278 @default.
- W2063516500 cites W2053405891 @default.
- W2063516500 cites W2054288808 @default.
- W2063516500 cites W2054542383 @default.
- W2063516500 cites W2056118398 @default.
- W2063516500 cites W2058357441 @default.
- W2063516500 cites W2060259273 @default.
- W2063516500 cites W2067235358 @default.
- W2063516500 cites W2067847775 @default.
- W2063516500 cites W2067887046 @default.
- W2063516500 cites W2068643687 @default.
- W2063516500 cites W2074349002 @default.
- W2063516500 cites W2084137696 @default.
- W2063516500 cites W2088173462 @default.
- W2063516500 cites W2096587816 @default.
- W2063516500 cites W2098079676 @default.
- W2063516500 cites W2100169057 @default.
- W2063516500 cites W2100419205 @default.
- W2063516500 cites W2101600215 @default.
- W2063516500 cites W2104976237 @default.
- W2063516500 cites W2106093126 @default.
- W2063516500 cites W2107464678 @default.
- W2063516500 cites W2110014181 @default.
- W2063516500 cites W2110564104 @default.
- W2063516500 cites W2111049471 @default.
- W2063516500 cites W2111625216 @default.
- W2063516500 cites W2112851172 @default.
- W2063516500 cites W2112972263 @default.
- W2063516500 cites W2116550356 @default.
- W2063516500 cites W2118503282 @default.
- W2063516500 cites W2122500867 @default.
- W2063516500 cites W2123705248 @default.
- W2063516500 cites W2125884100 @default.
- W2063516500 cites W2126241449 @default.
- W2063516500 cites W2126404587 @default.
- W2063516500 cites W2127290136 @default.
- W2063516500 cites W2127949919 @default.
- W2063516500 cites W2128421923 @default.