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• W2063521475 abstract "Apoptolidin (1) exhibits potent and highly selective apoptosis inducing activity against sensitive cancer cell lines and is hypothesized to act by inhibition of mitochondrial F0F1-ATP synthase. A series of apoptolidin derivatives, including a new intermolecular Diels−Alder adduct, were analyzed for antiproliferative activity in E1A-transformed rat fibroblasts. Potent F0F1-ATPase inhibition was not a sufficient determinant of antiproliferative activity for several analogues, suggesting the existence of a secondary biological target or more complex mode of action for apoptolidin." @default.
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• W2063521475 date "2006-01-14" @default.
• W2063521475 modified "2023-10-17" @default.
• W2063521475 title "Correlation of F₀F₁-ATPase Inhibition and Antiproliferative Activity of Apoptolidin Analogues" @default.
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• W2063521475 doi "https://doi.org/10.1021/ol052800q" @default.
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