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- W2063550139 abstract "The effect of various opiate agonists on the contraction of isolated rat atrium was investigated. Ethylketocyclazocine (EKC) (30-100 microM) and dynorphin-A(1-13) (10-30 microM), which are kappa-type agonists, caused positive inotropic effects on electrically stimulated left atrium in a dose-dependent manner. In addition, EKC decreased the frequency of spontaneous beating in the right atrium. Morphine (mu-type), [Met5]- and [Leu5]-enkephalin (delta-type) did not affect both the developed tension and frequency of contractions. These results indicate that the positive inotropic action is specific for kappa-type opiate agonists." @default.
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- W2063550139 date "1987-01-01" @default.
- W2063550139 modified "2023-09-26" @default.
- W2063550139 title "Positive inotropic action of .KAPPA. opiate agonists, ethylketocyclazocine and dynorphin-A(1-13), in isolated rat atrium." @default.
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- W2063550139 doi "https://doi.org/10.1254/jjp.45.125" @default.
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