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- W2063550150 endingPage "812" @default.
- W2063550150 startingPage "796" @default.
- W2063550150 abstract "Matrix metalloproteinase (MMP)-9 and neutrophil gelatinase-associated lipocalin (NGAL) have gained attention as cancer biomarkers. The inactive zymogen form of MMP-9 (pro-MMP-9) also exists as a disulphide-linked heterodimer bound to NGAL in humans. Leukaemias represent a heterogeneous group of neoplasms, which vary in their clinical behavior and pathophysiology. In this review, we summarize the current literature on the expression profiles of pro-MMP-9 and NGAL as prognostic factors in leukaemias. We also report the expression of the pro-MMP-9/NGAL complex in these diseases. We discuss the roles of (pro)-MMP-9 (active and latent forms) and NGAL in tumour development, and evaluate the mechanisms by which pro-MMP-9/NGAL may influence the actions of (pro)-MMP-9 and NGAL in cancer. Emerging knowledge about the coexpression and the biology of (pro)-MMP-9, NGAL and their complex in cancer including leukaemia may improve treatment outcomes." @default.
- W2063550150 created "2016-06-24" @default.
- W2063550150 creator A5029198329 @default.
- W2063550150 creator A5070668456 @default.
- W2063550150 date "2014-04-04" @default.
- W2063550150 modified "2023-10-05" @default.
- W2063550150 title "Neutrophil Gelatinase-Associated Lipocalin (NGAL), Pro-Matrix Metalloproteinase-9 (pro-MMP-9) and Their Complex Pro-MMP-9/NGAL in Leukaemias" @default.
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- W2063550150 doi "https://doi.org/10.3390/cancers6020796" @default.