FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063553411> ?p ?o ?g. }

• W2063553411 endingPage "E258" @default.
• W2063553411 startingPage "E251" @default.
• W2063553411 abstract "This study investigated mechanisms regulating hepatic insulin-like growth factor (IGF)-I class 1 and 2 mRNA levels. Lambs were treated with growth hormone (GH) either as an acute, single dose or over a longer term. Total hepatic unspliced, pre-mRNA levels increased after the single dose of GH but were attenuated after 8 days of GH, with exon 1- and 2-derived pre-mRNA levels displaying coordinate responses. Surprisingly, changes in total spliced, mature mRNA levels did not reflect those for pre-mRNA, instead being augmented after 8 days of GH. GH also induced a differential increase in the ratio of mature class 2-to-class 1 IGF-I mRNA; therefore, this must be predominantly via posttranscriptional mechanisms. Increases in the ratio of class 2-to-class 1 mRNA were observed in polysomal vs. total RNA preparations derived from GH-treated but not control lambs, indicating an increased proportion of class 2 transcripts engaged in translation. Our findings indicate that GH may stabilize mature class 2 transcripts or destabilize mature class 1 transcripts and that class 2 mRNA may have a greater translational potential. The following two main functions of hepatic class 2 IGF-I mRNA are suggested: an efficient “monitor” of GH status via providing a rapid negative feedback mechanism and a coordinator of endocrine-regulated tissue growth." @default.
• W2063553411 created "2016-06-24" @default.
• W2063553411 creator A5048991895 @default.
• W2063553411 creator A5072278778 @default.
• W2063553411 creator A5083948549 @default.
• W2063553411 date "2002-08-01" @default.
• W2063553411 modified "2023-10-17" @default.
• W2063553411 title "Regulation of IGF-I mRNA by GH: putative functions for class 1 and 2 message" @default.
• W2063553411 cites W1480912438 @default.
• W2063553411 cites W1536378179 @default.
• W2063553411 cites W1595565889 @default.
• W2063553411 cites W1965285733 @default.
• W2063553411 cites W1968902151 @default.
• W2063553411 cites W1971855331 @default.
• W2063553411 cites W1981667551 @default.
• W2063553411 cites W1983927889 @default.
• W2063553411 cites W1992571990 @default.
• W2063553411 cites W1997643031 @default.
• W2063553411 cites W2001522626 @default.
• W2063553411 cites W2003943524 @default.
• W2063553411 cites W2014305135 @default.
• W2063553411 cites W2020636054 @default.
• W2063553411 cites W2024267851 @default.
• W2063553411 cites W2028662837 @default.
• W2063553411 cites W2029770320 @default.
• W2063553411 cites W2039825798 @default.
• W2063553411 cites W2046054030 @default.
• W2063553411 cites W2050582644 @default.
• W2063553411 cites W2053217670 @default.
• W2063553411 cites W2054121324 @default.
• W2063553411 cites W2059438668 @default.
• W2063553411 cites W2065316371 @default.
• W2063553411 cites W2075425108 @default.
• W2063553411 cites W2077551460 @default.
• W2063553411 cites W2087090518 @default.
• W2063553411 cites W2106195121 @default.
• W2063553411 cites W2107163098 @default.
• W2063553411 cites W2117350664 @default.
• W2063553411 cites W2117720293 @default.
• W2063553411 cites W2120135871 @default.
• W2063553411 cites W2123321988 @default.
• W2063553411 cites W2137349730 @default.
• W2063553411 cites W2151298994 @default.
• W2063553411 cites W2576734941 @default.
• W2063553411 cites W4239682677 @default.
• W2063553411 cites W4294216491 @default.
• W2063553411 doi "https://doi.org/10.1152/ajpendo.00016.2002" @default.
• W2063553411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12110529" @default.
• W2063553411 hasPublicationYear "2002" @default.
• W2063553411 type Work @default.
• W2063553411 sameAs 2063553411 @default.
• W2063553411 citedByCount "21" @default.
• W2063553411 countsByYear W20635534112013 @default.
• W2063553411 countsByYear W20635534112014 @default.
• W2063553411 countsByYear W20635534112015 @default.
• W2063553411 countsByYear W20635534112020 @default.
• W2063553411 countsByYear W20635534112023 @default.
• W2063553411 crossrefType "journal-article" @default.
• W2063553411 hasAuthorship W2063553411A5048991895 @default.
• W2063553411 hasAuthorship W2063553411A5072278778 @default.
• W2063553411 hasAuthorship W2063553411A5083948549 @default.
• W2063553411 hasConcept C104317684 @default.
• W2063553411 hasConcept C105580179 @default.
• W2063553411 hasConcept C126322002 @default.
• W2063553411 hasConcept C134018914 @default.
• W2063553411 hasConcept C36823959 @default.
• W2063553411 hasConcept C54355233 @default.
• W2063553411 hasConcept C67705224 @default.
• W2063553411 hasConcept C71924100 @default.
• W2063553411 hasConcept C86803240 @default.
• W2063553411 hasConceptScore W2063553411C104317684 @default.
• W2063553411 hasConceptScore W2063553411C105580179 @default.
• W2063553411 hasConceptScore W2063553411C126322002 @default.
• W2063553411 hasConceptScore W2063553411C134018914 @default.
• W2063553411 hasConceptScore W2063553411C36823959 @default.
• W2063553411 hasConceptScore W2063553411C54355233 @default.
• W2063553411 hasConceptScore W2063553411C67705224 @default.
• W2063553411 hasConceptScore W2063553411C71924100 @default.
• W2063553411 hasConceptScore W2063553411C86803240 @default.
• W2063553411 hasIssue "2" @default.
• W2063553411 hasLocation W20635534111 @default.
• W2063553411 hasLocation W20635534112 @default.
• W2063553411 hasOpenAccess W2063553411 @default.
• W2063553411 hasPrimaryLocation W20635534111 @default.
• W2063553411 hasRelatedWork W1966504330 @default.
• W2063553411 hasRelatedWork W1966775726 @default.
• W2063553411 hasRelatedWork W1979139803 @default.
• W2063553411 hasRelatedWork W1991560548 @default.
• W2063553411 hasRelatedWork W2030889776 @default.
• W2063553411 hasRelatedWork W2037631372 @default.
• W2063553411 hasRelatedWork W2040058909 @default.
• W2063553411 hasRelatedWork W2063957970 @default.
• W2063553411 hasRelatedWork W2132898409 @default.
• W2063553411 hasRelatedWork W4249176446 @default.
• W2063553411 hasVolume "283" @default.
• W2063553411 isParatext "false" @default.
• W2063553411 isRetracted "false" @default.
• W2063553411 magId "2063553411" @default.

• next