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- W2063554264 abstract "Cardiac function was evaluated using computer-assisted analysis of M-mode echocardiograms in 36 patients with onset of type I diabetes (insulin-dependent diabetes) in childhood. None of the patients had clinical evidence for cardiovascular disease or microvascular disease. An impairment of diastolic function was observed in the older patients with long-standing diabetes. The time between minimal cavity dimension and mitral valve opening was significantly prolonged (P < 0.005), while the change of dimension in this time period and the change of dimension with rapid diastolic filling were normal. Although fractional shortening as a parameter of systolic function was normal in the diabetics, fractional shortening was inversely related to the mean HbA1 averaged over the last two years, reflecting the status of long-term metabolic control (P < 0.0008). The time between minimum cavity dimension and mitral opening was also related to the mean HbA1 averaged over the last two years (P < 0.0011). It is concluded that, with time, alterations of both systolic and diastolic function develop in children with type I diabetes. Their severity depends on the quality of metabolic control." @default.
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- W2063554264 date "1988-05-01" @default.
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- W2063554264 title "Cardiomyopathy in childhood diabetes mellitus: incidence, time of onset, and relation to metabolic control" @default.
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- W2063554264 doi "https://doi.org/10.1016/0167-5273(88)90083-6" @default.
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