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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063577510> ?p ?o ?g. }

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• W2063577510 abstract "Biarylamine-based inhibitors of Met kinase have been identified. Lead compounds demonstrate nanomolar potency in Met kinase biochemical assays and significant activity in the Met-driven GTL-16 human gastric carcinoma cell line. X-ray crystallography revealed that these compounds adopt a bioactive conformation, in the kinase domain, consistent with that previously seen with 2-pyridone-based Met kinase inhibitors. Compound 9b demonstrated potent in vivo antitumor activity in the GTL-16 human tumor xenograft model." @default.
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• W2063577510 date "2010-05-01" @default.
• W2063577510 modified "2023-09-24" @default.
• W2063577510 title "Design, synthesis and structure–activity relationships of novel biarylamine-based Met kinase inhibitors" @default.
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• W2063577510 doi "https://doi.org/10.1016/j.bmcl.2010.01.042" @default.
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