Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063582350> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2063582350 endingPage "402" @default.
- W2063582350 startingPage "396" @default.
- W2063582350 abstract "When the water-soluble cholesterol derivative, N-[tris [(beta-D-galactopyranosyloxy)methyl]methyl]-N alpha-[4-(5-cholesten-3 beta-yloxy)succinyl]glycinamide (tris-gal-chol) (Kempen et al. (1984) J. Medicin. Chem. 27, 1306-1312) is added as an aqueous micellar solution to a dispersion of small unilamellar phospholipid vesicles it rapidly associates with the vesicles, without causing significant leakage of liposome contents. Incorporation of 10 mol% tris-gal-chol in the liposomal membrane caused a substantial increase in the rate and extent of rat liver uptake and a shift in intrahepatic distribution of an intravenously administered dose of liposomes. For neutral liposomes composed of equimolar amounts of cholesterol and sphingomyelin incorporation of tris-gal-chol led to a 7-fold increase in total liver uptake, which was mainly accounted for by an increase in uptake by the Kupffer cells (12-fold) and by only a small increase in uptake by the hepatocytes (1.4-fold). The increased liver uptake is blocked by preinjection of N-acetyl-D-galactosamine and not affected by preinjection of N-acetyl-D-glucosamine. This indicates that the increased interaction of liposomes as a result of tris-gal-chol incorporation is mediated by galactose-specific recognition sites on both Kupffer cells and hepatocytes. Targeting of liposomes to the asialoglycoprotein receptor of the hepatocytes is thus frustrated by the highly active galactose-specific receptor on Kupffer cells. Comparable results on lactosylceramide incorporation into liposomes were recently reported by us (Spanjer et al. (1984) Biochim. Biophys. Acta 774, 49-55)." @default.
- W2063582350 created "2016-06-24" @default.
- W2063582350 creator A5023542851 @default.
- W2063582350 creator A5024733637 @default.
- W2063582350 creator A5045993003 @default.
- W2063582350 creator A5047666253 @default.
- W2063582350 date "1985-06-01" @default.
- W2063582350 modified "2023-09-27" @default.
- W2063582350 title "The effect of a water-soluble tris-galactoside terminated cholesterol derivative on the in vivo fate of small unilamellar vesicles in rats" @default.
- W2063582350 cites W1205458192 @default.
- W2063582350 cites W1519383911 @default.
- W2063582350 cites W1519847653 @default.
- W2063582350 cites W1596686502 @default.
- W2063582350 cites W1968072927 @default.
- W2063582350 cites W1969374259 @default.
- W2063582350 cites W1973342426 @default.
- W2063582350 cites W1975098083 @default.
- W2063582350 cites W1995798120 @default.
- W2063582350 cites W2012022784 @default.
- W2063582350 cites W2021646863 @default.
- W2063582350 cites W2030180759 @default.
- W2063582350 cites W2034127662 @default.
- W2063582350 cites W2046553940 @default.
- W2063582350 cites W2054233269 @default.
- W2063582350 cites W2054392760 @default.
- W2063582350 cites W2080374410 @default.
- W2063582350 cites W2204518242 @default.
- W2063582350 cites W2410890562 @default.
- W2063582350 doi "https://doi.org/10.1016/0005-2736(85)90507-3" @default.
- W2063582350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3890947" @default.
- W2063582350 hasPublicationYear "1985" @default.
- W2063582350 type Work @default.
- W2063582350 sameAs 2063582350 @default.
- W2063582350 citedByCount "28" @default.
- W2063582350 countsByYear W20635823502014 @default.
- W2063582350 countsByYear W20635823502019 @default.
- W2063582350 crossrefType "journal-article" @default.
- W2063582350 hasAuthorship W2063582350A5023542851 @default.
- W2063582350 hasAuthorship W2063582350A5024733637 @default.
- W2063582350 hasAuthorship W2063582350A5045993003 @default.
- W2063582350 hasAuthorship W2063582350A5047666253 @default.
- W2063582350 hasConcept C11569505 @default.
- W2063582350 hasConcept C130316041 @default.
- W2063582350 hasConcept C150903083 @default.
- W2063582350 hasConcept C181199279 @default.
- W2063582350 hasConcept C185154212 @default.
- W2063582350 hasConcept C185592680 @default.
- W2063582350 hasConcept C202751555 @default.
- W2063582350 hasConcept C207001950 @default.
- W2063582350 hasConcept C2776200302 @default.
- W2063582350 hasConcept C2776392439 @default.
- W2063582350 hasConcept C2778163477 @default.
- W2063582350 hasConcept C2778918659 @default.
- W2063582350 hasConcept C2781014771 @default.
- W2063582350 hasConcept C41625074 @default.
- W2063582350 hasConcept C55493867 @default.
- W2063582350 hasConcept C61322309 @default.
- W2063582350 hasConcept C86803240 @default.
- W2063582350 hasConceptScore W2063582350C11569505 @default.
- W2063582350 hasConceptScore W2063582350C130316041 @default.
- W2063582350 hasConceptScore W2063582350C150903083 @default.
- W2063582350 hasConceptScore W2063582350C181199279 @default.
- W2063582350 hasConceptScore W2063582350C185154212 @default.
- W2063582350 hasConceptScore W2063582350C185592680 @default.
- W2063582350 hasConceptScore W2063582350C202751555 @default.
- W2063582350 hasConceptScore W2063582350C207001950 @default.
- W2063582350 hasConceptScore W2063582350C2776200302 @default.
- W2063582350 hasConceptScore W2063582350C2776392439 @default.
- W2063582350 hasConceptScore W2063582350C2778163477 @default.
- W2063582350 hasConceptScore W2063582350C2778918659 @default.
- W2063582350 hasConceptScore W2063582350C2781014771 @default.
- W2063582350 hasConceptScore W2063582350C41625074 @default.
- W2063582350 hasConceptScore W2063582350C55493867 @default.
- W2063582350 hasConceptScore W2063582350C61322309 @default.
- W2063582350 hasConceptScore W2063582350C86803240 @default.
- W2063582350 hasIssue "2" @default.
- W2063582350 hasLocation W20635823501 @default.
- W2063582350 hasLocation W20635823502 @default.
- W2063582350 hasOpenAccess W2063582350 @default.
- W2063582350 hasPrimaryLocation W20635823501 @default.
- W2063582350 hasRelatedWork W2009857196 @default.
- W2063582350 hasRelatedWork W2011836061 @default.
- W2063582350 hasRelatedWork W2015057423 @default.
- W2063582350 hasRelatedWork W2063582350 @default.
- W2063582350 hasRelatedWork W2074880885 @default.
- W2063582350 hasRelatedWork W2084404464 @default.
- W2063582350 hasRelatedWork W2120474689 @default.
- W2063582350 hasRelatedWork W2410967278 @default.
- W2063582350 hasRelatedWork W2424731836 @default.
- W2063582350 hasRelatedWork W2468529627 @default.
- W2063582350 hasVolume "816" @default.
- W2063582350 isParatext "false" @default.
- W2063582350 isRetracted "false" @default.
- W2063582350 magId "2063582350" @default.
- W2063582350 workType "article" @default.