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• W2063584103 abstract "The aim of this prospective epidemiological study was to determine the incidence of inflammatory bowel diseases (IBD) in Corsica using the same methodology as that of the EPIMAD registry. Between January 1st, 2002 and December 31, 2003, all gastroenterologists in Corsica (N19) enrolled patients consulting for the first time with clinical symptoms compatible with IBD. Each case was reviewed by another expert gastroenterologist to assign a diagnosis of definite, probable, possible Crohn's disease (CD), ulcerative colitis (UC) or unclassified/able chronic colitis. Eighty-one new cases were recorded, including seventy-one diagnoses of IBD (definite and probable cases), with 20 (28%) CD, 49 (69%) UC and 2 (3%) unclassifiable chronic colitis. The age-adjusted incidence (per 105 inhabitants/year) was 4.05 for CD and 9.5 for UC. The female/male ratio and median age at time of diagnosis were 1.3 and 29 years for CD and 0.63 and 44 years for UC, respectively. The median time from symptom onset to diagnosis was five months for both diseases. In Corsica, the observed incidence of CD is close to that observed in other metropolitan French regions. These data are contrary to the north-south gradient reported for this disease. Our figure of 9.5/105 for UC in Corsica is two-fold higher than reported in other metropolitan French regions. Genetic and/or environmental factors may explain these findings. Évaluer de manière prospective l’incidence des maladies inflammatoires cryptogénétiques intestinales (MICI) en Corse selon la méthodologie du registre EPIMAD. Du 1er janvier 2002 au 31 décembre 2003 tous les gastroentérologues (N19) de Corse ont recensé les cas incidents de MICI. Tous les dossiers de maladie de Crohn (MC), de rectocolite hémorragique (RCH) et de colites chroniques inclassables (CCI) étaient classés par un gastroentérologue référent en cas certains, probables ou possibles. Quatre-vingt-un cas ont été répertoriés dont 71 cas de MICI incluant uniquement les cas certains et probables. Ces 71 cas étaient repartis en 20 (28 %) MC, 49 (69 %) RCH et 2 (3 %) CCI. L’incidence standardisée à l’âge (pour 105 habitants/an) était de 4,05 pour la MC et de 9,5 pour la RCH. Le sex-ratio (femme/homme) était de 1,3 pour la MC et de 0,63 pour la RCH. L’âge médian au moment du diagnostic était de 29 ans pour la MC et de 44 ans pour la RCH. Le délai médian entre le début des symptômes et le diagnostic était de 5 mois pour les deux affections. En Corse, l’incidence de la MC est proche de celle observée dans les autres régions de France métropolitaine ; ce qui va contre la notion de gradient nord-sud pour cette affection. L’incidence de la RCH est plus de deux fois supérieure à celle des autres régions de France. Il pourrait donc exister en Corse des caractéristiques génétiques et/ou environnementales particulières favorisant l’émergence de la RCH." @default.
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• W2063584103 date "2007-12-01" @default.
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• W2063584103 title "Incidence of inflammatory bowel disease in Corsica from 2002 to 2003" @default.
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• W2063584103 doi "https://doi.org/10.1016/s0399-8320(07)78343-4" @default.
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