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- W2063590060 abstract "The monocrotaline (MCT) and chronically hypoxic rat models of pulmonary hypertension mimic various aspects of human primary pulmonary hypertension. A feature common to all forms of pulmonary hypertension is that the initial hypertensive stimuli lead to progressive vascular thickening, which underlies sustained, irreversible increases in pulmonary arterial pressure. This pulmonary vascular remodeling process requires increased protein and RNA and DNA synthesis, and is associated with vascular cell proliferation, hypertrophy, and differentiation. In this context, the polyamines (putrescine, spermidine, and spermine), which are generally considered to be essential for cellular synthesis of protein, RNA, and DNA, appear to comprise an obligatory link between the initial hypertensive stimuli and the vascular remodeling process. 1 Olson JW Atkinson JE Hacker AD Altiere RJ Gillespie MN Suspension of polyamine biosynthesis prevents monocrotaline-induced pulmonary edema and arterial medial thickening. Toxicol Appl Pharmacol. 1985; 81: 91-99 Crossref PubMed Scopus (37) Google Scholar , 2 Atkinson JE Olson JW Altiere RJ Gillespie MN Evidence that hypoxic pulmonary vascular remodeling in rats is polyamine dependent. J Appl Physiol. 1987; 62: 1562-1568 PubMed Google Scholar Previous studies from our laboratories indicated that MCT and chronic hypoxia enhance lung polyamine biosynthesis and blockade of the initial enzyme in polyamine biosynthesis, ornithine decarboxylase (ODC), with the highly specific suicide inhibitor difluoromethylornithine (DFMO), attenuates the progressive medial arterial thickening and prevents sustained pulmonary hypertension. 1 Olson JW Atkinson JE Hacker AD Altiere RJ Gillespie MN Suspension of polyamine biosynthesis prevents monocrotaline-induced pulmonary edema and arterial medial thickening. Toxicol Appl Pharmacol. 1985; 81: 91-99 Crossref PubMed Scopus (37) Google Scholar , 2 Atkinson JE Olson JW Altiere RJ Gillespie MN Evidence that hypoxic pulmonary vascular remodeling in rats is polyamine dependent. J Appl Physiol. 1987; 62: 1562-1568 PubMed Google Scholar Further experiments indicated that putrescine reversed the protection against MCT afforded by DFMO, thus substantiating a central role for polyamines in the MCT-induced vascular remodeling process." @default.
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- W2063590060 date "1988-03-01" @default.
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- W2063590060 title "Growth Factors and Diacylglycerol Stimulate Pulmonary Vascular Endothelial Ornithine Decarboxylase Activity" @default.
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- W2063590060 doi "https://doi.org/10.1378/chest.93.3_supplement.168s" @default.
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