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- W2063593981 abstract "Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DCBone Morphogenetic Proteins (BMPs) are members of the Transforming Growth Factor β (TGFβ) superfamily of signaling molecules. BMPs can elicit a wide range of effects in many cell types and have previously been shown to induce growth arrest in cancers as well as normal epithelia. Recently, it has been demonstrated that BMP4 and BMP7 are overexpressed in human breast cancers. We sought to understand how a potential tumor suppressor could be overexpressed in human breast cancers. We analyzed several tumor cell lines and normal mammary epithelia and found that BMPs are sufficient to induce growth arrest in normal and transformed mammary epithelia. Surprisingly, when we treated cells derived from the PyVmT mouse model lacking the type II TGFβ receptor with BMP-4, these cells failed to undergo growth arrest. We determined by flow cytometry that BMP treated cells did not undergo apoptosis. Cell cycle analysis demonstrated that cells with functional TGFβ signaling were arrested in G1 and cells lacking TGFβ signaling capabilities remained in a typical distribution of the cell cycle. We also found that Smads which mediate both BMP and TGFβ signaling were not only still present, but also responsive to BMP stimulation resulting in BMP Smad1/5/8 phosphorylation. Furthermore, we assessed the ability for synergy between BMP-4 and TGFβ1 and found that BMP-4 could induce an increased growth response in the presence of maximal TGFβ inhibition. We conclude that the dual functions of TGFβ as a tumor suppressor and promoter are connected to a BMP mediated tumor suppressive mechanism that shares common and distinct pathways.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3840." @default.
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- W2063593981 date "2010-04-15" @default.
- W2063593981 modified "2023-09-26" @default.
- W2063593981 title "Abstract 3840: Bone morphogenetic proteins require the type II TGFβ receptor for growth arrest in mammary tumor cells" @default.
- W2063593981 doi "https://doi.org/10.1158/1538-7445.am10-3840" @default.
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