FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063595713> ?p ?o ?g. }

• W2063595713 endingPage "730" @default.
• W2063595713 startingPage "723" @default.
• W2063595713 abstract "Oxidative stress is considered to be implicated in the pathophysiology of breast cancers. In this study we investigated the level of oxidative stress and antioxidant (AO) status in the blood of breast cancer patients of different ages. The level of lipid hydroperoxides (LP) was measured in blood plasma and the activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) enzymes, as well as the level of total glutathione (GSH) and CuZnSOD protein were measured in blood cells of breast cancer patients and age-matched healthy subjects. Our results showed that breast carcinoma is related to increase of lipid peroxidation in plasma with concomitant decrease of AO defense capacity in blood cells, which becomes more pronounced during aging of the patients. Suppression of CuZnSOD activity related to breast cancer is most likely caused by decreased de novo synthesis of this enzyme. Similar patterns of suppression in CuZnSOD and CAT activities related to aging were recorded both in controls and patients. Age-related decrease in CuZnSOD activity seems not to be caused by altered protein levels of this enzyme. Suppression of AO enzymes associated with breast cancer and aging is most likely the cause of increased levels of reactive oxygen species (ROS). Our results indicate significant role of oxidative-induced injury in the breast carcinogenesis, particularly during the later stages of aging. Overall, our data support the importance of endogenous AOs in the etiology of breast cancer across all levels of predicted risk. Copyright © 2008 John Wiley & Sons, Ltd." @default.
• W2063595713 created "2016-06-24" @default.
• W2063595713 creator A5015251324 @default.
• W2063595713 creator A5058927990 @default.
• W2063595713 creator A5069753678 @default.
• W2063595713 creator A5080994429 @default.
• W2063595713 creator A5083236485 @default.
• W2063595713 date "2008-08-01" @default.
• W2063595713 modified "2023-09-25" @default.
• W2063595713 title "Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages" @default.
• W2063595713 cites W1601027696 @default.
• W2063595713 cites W160949418 @default.
• W2063595713 cites W1663251599 @default.
• W2063595713 cites W1775749144 @default.
• W2063595713 cites W1782880405 @default.
• W2063595713 cites W1955393669 @default.
• W2063595713 cites W1975829552 @default.
• W2063595713 cites W1984788347 @default.
• W2063595713 cites W1996303229 @default.
• W2063595713 cites W2019622511 @default.
• W2063595713 cites W2020424703 @default.
• W2063595713 cites W2020582607 @default.
• W2063595713 cites W2027605252 @default.
• W2063595713 cites W2028282157 @default.
• W2063595713 cites W2041017432 @default.
• W2063595713 cites W2045160022 @default.
• W2063595713 cites W2048155244 @default.
• W2063595713 cites W2049212848 @default.
• W2063595713 cites W2054211750 @default.
• W2063595713 cites W2060778476 @default.
• W2063595713 cites W2070666438 @default.
• W2063595713 cites W2071687327 @default.
• W2063595713 cites W2094565485 @default.
• W2063595713 cites W2100837269 @default.
• W2063595713 cites W2109243861 @default.
• W2063595713 cites W2115220780 @default.
• W2063595713 cites W2147670431 @default.
• W2063595713 cites W2156237864 @default.
• W2063595713 cites W2313934125 @default.
• W2063595713 cites W2319302105 @default.
• W2063595713 doi "https://doi.org/10.1002/cbf.1499" @default.
• W2063595713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18636415" @default.
• W2063595713 hasPublicationYear "2008" @default.
• W2063595713 type Work @default.
• W2063595713 sameAs 2063595713 @default.
• W2063595713 citedByCount "85" @default.
• W2063595713 countsByYear W20635957132012 @default.
• W2063595713 countsByYear W20635957132013 @default.
• W2063595713 countsByYear W20635957132014 @default.
• W2063595713 countsByYear W20635957132015 @default.
• W2063595713 countsByYear W20635957132016 @default.
• W2063595713 countsByYear W20635957132017 @default.
• W2063595713 countsByYear W20635957132018 @default.
• W2063595713 countsByYear W20635957132019 @default.
• W2063595713 countsByYear W20635957132020 @default.
• W2063595713 countsByYear W20635957132021 @default.
• W2063595713 countsByYear W20635957132022 @default.
• W2063595713 countsByYear W20635957132023 @default.
• W2063595713 crossrefType "journal-article" @default.
• W2063595713 hasAuthorship W2063595713A5015251324 @default.
• W2063595713 hasAuthorship W2063595713A5058927990 @default.
• W2063595713 hasAuthorship W2063595713A5069753678 @default.
• W2063595713 hasAuthorship W2063595713A5080994429 @default.
• W2063595713 hasAuthorship W2063595713A5083236485 @default.
• W2063595713 hasConcept C121608353 @default.
• W2063595713 hasConcept C126322002 @default.
• W2063595713 hasConcept C134018914 @default.
• W2063595713 hasConcept C165069038 @default.
• W2063595713 hasConcept C181199279 @default.
• W2063595713 hasConcept C185592680 @default.
• W2063595713 hasConcept C2775838275 @default.
• W2063595713 hasConcept C2776151105 @default.
• W2063595713 hasConcept C2778004101 @default.
• W2063595713 hasConcept C2778760513 @default.
• W2063595713 hasConcept C2778979269 @default.
• W2063595713 hasConcept C2780829032 @default.
• W2063595713 hasConcept C48349386 @default.
• W2063595713 hasConcept C530470458 @default.
• W2063595713 hasConcept C538909803 @default.
• W2063595713 hasConcept C55493867 @default.
• W2063595713 hasConcept C71924100 @default.
• W2063595713 hasConceptScore W2063595713C121608353 @default.
• W2063595713 hasConceptScore W2063595713C126322002 @default.
• W2063595713 hasConceptScore W2063595713C134018914 @default.
• W2063595713 hasConceptScore W2063595713C165069038 @default.
• W2063595713 hasConceptScore W2063595713C181199279 @default.
• W2063595713 hasConceptScore W2063595713C185592680 @default.
• W2063595713 hasConceptScore W2063595713C2775838275 @default.
• W2063595713 hasConceptScore W2063595713C2776151105 @default.
• W2063595713 hasConceptScore W2063595713C2778004101 @default.
• W2063595713 hasConceptScore W2063595713C2778760513 @default.
• W2063595713 hasConceptScore W2063595713C2778979269 @default.
• W2063595713 hasConceptScore W2063595713C2780829032 @default.
• W2063595713 hasConceptScore W2063595713C48349386 @default.
• W2063595713 hasConceptScore W2063595713C530470458 @default.
• W2063595713 hasConceptScore W2063595713C538909803 @default.
• W2063595713 hasConceptScore W2063595713C55493867 @default.
• W2063595713 hasConceptScore W2063595713C71924100 @default.

• next