Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063613426> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2063613426 endingPage "165" @default.
- W2063613426 startingPage "157" @default.
- W2063613426 abstract "In retrovirus-induced tumors, proviral DNA is commonly found next to or within a cellular proto-oncogene such that transcription of the gene is influenced by the viral promoter or enhancer. Extensive surveys of naturally occurring tumors reveal that proviruses integrated on the 3′ side of the gene are usually in the same transcriptional orientation, suggesting a model in which the bidirectional viral enhancer acts primarily on the closest promoters. Here we describe a virally induced mammary tumor that appears to contradict these ideas since the Wnt- 1/int-1 and Fgf-3/int-2 proto-oncogenes have both been activated by mouse mammary tumor virus (MMTV) DNA integrated 3′ of the gene in the opposite transcriptional orientation. However, by cloning the relevant DNAs, we show that these are not simple proviral insertions. In the Wnt-1 locus, there is an additional LTR immediately adjacent to the 3′ end of the MMTV provirus, while in Fgf-3 , the provirus has sustained a deletion that removes the 5′ LTR, gag, and most of pol. These structural alterations can be reconciled with the enhancer insertion model by postulating that the viral enhancer can only function if it is not transcribed." @default.
- W2063613426 created "2016-06-24" @default.
- W2063613426 creator A5016443916 @default.
- W2063613426 creator A5021987710 @default.
- W2063613426 creator A5037675485 @default.
- W2063613426 creator A5038858265 @default.
- W2063613426 creator A5046014278 @default.
- W2063613426 creator A5051758709 @default.
- W2063613426 date "1993-05-01" @default.
- W2063613426 modified "2023-09-27" @default.
- W2063613426 title "Activation of Both Wnt-1 and Fgf-3 by Insertion of Mouse Mammary Tumor Virus Downstream in the Reverse Orientation: A Reappraisal of the Enhancer Insertion Model" @default.
- W2063613426 doi "https://doi.org/10.1006/viro.1993.1245" @default.
- W2063613426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8386870" @default.
- W2063613426 hasPublicationYear "1993" @default.
- W2063613426 type Work @default.
- W2063613426 sameAs 2063613426 @default.
- W2063613426 citedByCount "25" @default.
- W2063613426 countsByYear W20636134262012 @default.
- W2063613426 countsByYear W20636134262015 @default.
- W2063613426 countsByYear W20636134262016 @default.
- W2063613426 countsByYear W20636134262022 @default.
- W2063613426 countsByYear W20636134262023 @default.
- W2063613426 crossrefType "journal-article" @default.
- W2063613426 hasAuthorship W2063613426A5016443916 @default.
- W2063613426 hasAuthorship W2063613426A5021987710 @default.
- W2063613426 hasAuthorship W2063613426A5037675485 @default.
- W2063613426 hasAuthorship W2063613426A5038858265 @default.
- W2063613426 hasAuthorship W2063613426A5046014278 @default.
- W2063613426 hasAuthorship W2063613426A5051758709 @default.
- W2063613426 hasConcept C101762097 @default.
- W2063613426 hasConcept C102906071 @default.
- W2063613426 hasConcept C104317684 @default.
- W2063613426 hasConcept C111936080 @default.
- W2063613426 hasConcept C138885662 @default.
- W2063613426 hasConcept C141231307 @default.
- W2063613426 hasConcept C150194340 @default.
- W2063613426 hasConcept C153911025 @default.
- W2063613426 hasConcept C179926584 @default.
- W2063613426 hasConcept C199491388 @default.
- W2063613426 hasConcept C21784809 @default.
- W2063613426 hasConcept C2778431562 @default.
- W2063613426 hasConcept C2779777497 @default.
- W2063613426 hasConcept C2781018059 @default.
- W2063613426 hasConcept C29537977 @default.
- W2063613426 hasConcept C41895202 @default.
- W2063613426 hasConcept C54355233 @default.
- W2063613426 hasConcept C86339819 @default.
- W2063613426 hasConcept C86803240 @default.
- W2063613426 hasConceptScore W2063613426C101762097 @default.
- W2063613426 hasConceptScore W2063613426C102906071 @default.
- W2063613426 hasConceptScore W2063613426C104317684 @default.
- W2063613426 hasConceptScore W2063613426C111936080 @default.
- W2063613426 hasConceptScore W2063613426C138885662 @default.
- W2063613426 hasConceptScore W2063613426C141231307 @default.
- W2063613426 hasConceptScore W2063613426C150194340 @default.
- W2063613426 hasConceptScore W2063613426C153911025 @default.
- W2063613426 hasConceptScore W2063613426C179926584 @default.
- W2063613426 hasConceptScore W2063613426C199491388 @default.
- W2063613426 hasConceptScore W2063613426C21784809 @default.
- W2063613426 hasConceptScore W2063613426C2778431562 @default.
- W2063613426 hasConceptScore W2063613426C2779777497 @default.
- W2063613426 hasConceptScore W2063613426C2781018059 @default.
- W2063613426 hasConceptScore W2063613426C29537977 @default.
- W2063613426 hasConceptScore W2063613426C41895202 @default.
- W2063613426 hasConceptScore W2063613426C54355233 @default.
- W2063613426 hasConceptScore W2063613426C86339819 @default.
- W2063613426 hasConceptScore W2063613426C86803240 @default.
- W2063613426 hasIssue "1" @default.
- W2063613426 hasLocation W20636134261 @default.
- W2063613426 hasLocation W20636134262 @default.
- W2063613426 hasOpenAccess W2063613426 @default.
- W2063613426 hasPrimaryLocation W20636134261 @default.
- W2063613426 hasRelatedWork W1592614069 @default.
- W2063613426 hasRelatedWork W1718103699 @default.
- W2063613426 hasRelatedWork W1745115363 @default.
- W2063613426 hasRelatedWork W1846452751 @default.
- W2063613426 hasRelatedWork W2063613426 @default.
- W2063613426 hasRelatedWork W2126201788 @default.
- W2063613426 hasRelatedWork W2136760742 @default.
- W2063613426 hasRelatedWork W2169725472 @default.
- W2063613426 hasRelatedWork W3131956349 @default.
- W2063613426 hasRelatedWork W4225378678 @default.
- W2063613426 hasVolume "194" @default.
- W2063613426 isParatext "false" @default.
- W2063613426 isRetracted "false" @default.
- W2063613426 magId "2063613426" @default.
- W2063613426 workType "article" @default.