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• W2063618315 abstract "Kink turns (k-turns) are important structural motifs that create a sharp axial bend in RNA. Most conform to a consensus in which a three-nucleotide bulge is followed by consecutive G•A and A•G base pairs, and when these G•A pairs are modified in vitro this generally leads to a failure to adopt the k-turn conformation. Kt-23 in the 30S ribosomal subunit of Thermus thermophilus is a rare exception in which the bulge-distal A•G pair is replaced by a non-Watson–Crick A•U pair. In the context of the ribosome, Kt-23 adopts a completely conventional k-turn geometry. We show here that this sequence is induced to fold into a k-turn structure in an isolated RNA duplex by Mg2+ or Na+ ions. Therefore, the Kt-23 is intrinsically stable despite lacking the key A•G pair; its formation requires neither tertiary interactions nor protein binding. Moreover, the Kt-23 k-turn is stabilized by the same critical hydrogen-bonding interactions within the core of the structure that are found in more conventional sequences such as the near-consensus Kt-7. T. thermophilus Kt-23 has two further non-Watson–Crick base pairs within the non-canonical helix, three and four nucleotides from the bulge, and we find that the nature of these pairs influences the ability of the RNA to adopt k-turn conformation, although the base pair adjacent to the A•U pair is more important than the other." @default.
• W2063618315 created "2016-06-24" @default.
• W2063618315 creator A5036989987 @default.
• W2063618315 creator A5054701391 @default.
• W2063618315 date "2009-09-26" @default.
• W2063618315 modified "2023-10-14" @default.
• W2063618315 title "Ion-induced folding of a kink turn that departs from the conventional sequence" @default.
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• W2063618315 doi "https://doi.org/10.1093/nar/gkp791" @default.
• W2063618315 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2790904" @default.
• W2063618315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19783814" @default.
• W2063618315 hasPublicationYear "2009" @default.
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