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• W2063623029 abstract "The change in the modality of cornification from embryonic to definitive epidermis in the chick has been studied using immunocytochemistry and electron microscopy to show that the initial soft cornification based on an acidic type I alpha-keratin transits to a definitive hard cornification based on beta-proteins in the claw, scales and feathers. The first two periderm layers contain acidic keratins associated with periderm granules and participate in a mild form of cornification before shedding of the periderm. The transition from embryonic to adult cornification is best seen in the transitional layers of the claw where numerous periderm granules merge with packets or bundles of corneous beta-proteins. This process is hardly seen in scale and feathers where periderm granules remain most in the periderm or in the feather sheath. Periderm granules disappear in corneocytes generated underneath the periderm in scales or in the transitional layer in claws and are replaced by beta-proteins associated to other types of acidic alpha-keratins. This process produces a mechanically resistant corneous material underneath the softer periderm, adapted to terrestrial demand for mechanical protection in scales and in the dorsal part of the claw, the unguis. In the ventral part of the claw, the sub-unguis, scarce or no beta-proteins are accumulated resulting in a softer corneous layer. The study indicates that specific alpha-keratins form the cytoskeletal framework of definitive corneocytes in claws, scales and feathers, and that specialized corneous beta-proteins are deposited over this framework to produce epidermal layers with higher mechanical resistance." @default.
• W2063623029 created "2016-06-24" @default.
• W2063623029 creator A5045239901 @default.
• W2063623029 date "2014-10-01" @default.
• W2063623029 modified "2023-09-26" @default.
• W2063623029 title "Immunodetection of type I acidic keratins associated to periderm granules during the transition of cornification from embryonic to definitive chick epidermis" @default.
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• W2063623029 doi "https://doi.org/10.1016/j.micron.2014.04.002" @default.
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• W2063623029 hasPublicationYear "2014" @default.
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