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- W2063624986 abstract "Liver transplantation (LT) is a treatment option in select patients with hepatocellular carcinoma (HCC). The aim of the present study was to compare survival in Stage I or II HCC patients undergoing either liver transplant (LT) or a liver resection (LR).The study is a retrospective analysis of the National Cancer Data Base (1998–2011). In total, 148 882 patients with liver cancer were identified, of which 5-year survival data (1998–2006) were available for 64 227 patients. Patients were stratified by the American Joint Committee on Cancer (AJCC) clinical stage I and II. Kaplan–Meier curves and log-rank tests were used for statistical analysis.3340 HCC patients met analysis criteria. Among stage I HCC, 860 had LT and 871 had LR. Among stage II HCC, 833 had LT and 776 LR. In stage I patients the median survival for LT and LR were 127.9 and 56.7 months, respectively, (P < 0.0001) and in stage II patients the median survival was 110.8 and 42.8 months (P < 0.0001). Unlike LT patients, LR patients with Stage I HCC had a longer median survival compared with Stage II patients (P = 0.0002).Liver transplantation offers a survival advantage compared with a liver resection among patients with Stage I and II HCC. LT is the best surgical treatment for early stage (I/II) HCC in patients with advanced fibrosis or cirrhosis, whereas LR provides equivalent outcomes to LT in patients without advanced fibrosis and should be considered as the first surgical option." @default.
- W2063624986 created "2016-06-24" @default.
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- W2063624986 date "1999-02-01" @default.
- W2063624986 modified "2023-10-16" @default.
- W2063624986 title "Is liver transplantation superior to resection in early stage hepatocellular carcinoma?" @default.
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- W2063624986 doi "https://doi.org/10.1016/s0041-1345(98)01727-8" @default.
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