FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063632703> ?p ?o ?g. }

• W2063632703 endingPage "34" @default.
• W2063632703 startingPage "27" @default.
• W2063632703 abstract "Exostosin 1 (EXT1) is a glycosyltransferase that contributes to the biosynthesis of heparan sulfate proteoglycans (HSPG). Loss of ext1 function leads to the human genetic disorder hereditary multiple exostoses (HME) and inhibits development in mouse, zebrafish and Drosophila. In Xenopus, loss of maternal EXT1 leads to impaired wnt11 signaling, resulting in a loss of dorsal embryonic development (Tao et al., 2005), but the functions of zygotic ext1 have not been elucidated. In this study, morpholino oligonucleotides were used to generate a zygotic partial loss of function for ext1, in order to evaluate the requirements for ext1 function in gastrulation and paracrine signaling. Transcriptional profiling was carried out by microarray. Validation and subsequent analyses of gene expression were performed using Q-RT-PCR and in situ hybridization. Western blots were used to assess paracrine signaling pathway activity. Introduction of ext1 MO led to gastrulation defects, which were partially rescued by co-injection of ext1 mRNA. Microarray-based comparisons of gene expression in control vs. Ext1 MO embryos identified several developmentally significant genes that are dependent upon Ext1 function, including brachyury (Xbra). In addition, decreased Ext1 was shown to reduce the level of Wnt8 and BMP4 signaling and disrupt ventral-specific gene expression. Ext1 function is required for maintenance of normal levels of BMP and wnt, as well as their target genes. In addition, expression of xbra and the establishment of ventral mesoderm depend upon normal levels of Ext1. These findings suggest that ext1-dependent synthesis of HSPG is critical for wnt and BMP signaling, mesodermal identity, and ventral pattern." @default.
• W2063632703 created "2016-06-24" @default.
• W2063632703 creator A5001884138 @default.
• W2063632703 creator A5022822060 @default.
• W2063632703 creator A5071669726 @default.
• W2063632703 date "2014-01-01" @default.
• W2063632703 modified "2023-09-25" @default.
• W2063632703 title "Zygotic expression of Exostosin1 (Ext1) is required for BMP signaling and establishment of dorsal-ventral pattern in Xenopus" @default.
• W2063632703 cites W1972899777 @default.
• W2063632703 cites W1981006004 @default.
• W2063632703 cites W1984853905 @default.
• W2063632703 cites W1989709392 @default.
• W2063632703 cites W1991102621 @default.
• W2063632703 cites W2008575029 @default.
• W2063632703 cites W2010854221 @default.
• W2063632703 cites W2014029497 @default.
• W2063632703 cites W2027097677 @default.
• W2063632703 cites W2032231544 @default.
• W2063632703 cites W2033588416 @default.
• W2063632703 cites W2039806395 @default.
• W2063632703 cites W2040003312 @default.
• W2063632703 cites W2041578059 @default.
• W2063632703 cites W2044386822 @default.
• W2063632703 cites W2046268574 @default.
• W2063632703 cites W2057364465 @default.
• W2063632703 cites W2078326203 @default.
• W2063632703 cites W2082114794 @default.
• W2063632703 cites W2087276951 @default.
• W2063632703 cites W2095373191 @default.
• W2063632703 cites W2099540110 @default.
• W2063632703 cites W2111955181 @default.
• W2063632703 cites W2112067413 @default.
• W2063632703 cites W2118707662 @default.
• W2063632703 cites W2140261464 @default.
• W2063632703 cites W2151804327 @default.
• W2063632703 doi "https://doi.org/10.1387/ijdb.130257as" @default.
• W2063632703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24860992" @default.
• W2063632703 hasPublicationYear "2014" @default.
• W2063632703 type Work @default.
• W2063632703 sameAs 2063632703 @default.
• W2063632703 citedByCount "7" @default.
• W2063632703 countsByYear W20636327032014 @default.
• W2063632703 countsByYear W20636327032015 @default.
• W2063632703 countsByYear W20636327032016 @default.
• W2063632703 countsByYear W20636327032017 @default.
• W2063632703 countsByYear W20636327032018 @default.
• W2063632703 countsByYear W20636327032021 @default.
• W2063632703 crossrefType "journal-article" @default.
• W2063632703 hasAuthorship W2063632703A5001884138 @default.
• W2063632703 hasAuthorship W2063632703A5022822060 @default.
• W2063632703 hasAuthorship W2063632703A5071669726 @default.
• W2063632703 hasBestOaLocation W20636327031 @default.
• W2063632703 hasConcept C104317684 @default.
• W2063632703 hasConcept C111936080 @default.
• W2063632703 hasConcept C129536746 @default.
• W2063632703 hasConcept C136571751 @default.
• W2063632703 hasConcept C137620995 @default.
• W2063632703 hasConcept C145103041 @default.
• W2063632703 hasConcept C150194340 @default.
• W2063632703 hasConcept C153911025 @default.
• W2063632703 hasConcept C170493617 @default.
• W2063632703 hasConcept C196843134 @default.
• W2063632703 hasConcept C205583638 @default.
• W2063632703 hasConcept C2776735322 @default.
• W2063632703 hasConcept C2776878037 @default.
• W2063632703 hasConcept C2779535977 @default.
• W2063632703 hasConcept C2780915607 @default.
• W2063632703 hasConcept C54355233 @default.
• W2063632703 hasConcept C62478195 @default.
• W2063632703 hasConcept C7876069 @default.
• W2063632703 hasConcept C83484664 @default.
• W2063632703 hasConcept C86803240 @default.
• W2063632703 hasConcept C87073359 @default.
• W2063632703 hasConcept C95444343 @default.
• W2063632703 hasConceptScore W2063632703C104317684 @default.
• W2063632703 hasConceptScore W2063632703C111936080 @default.
• W2063632703 hasConceptScore W2063632703C129536746 @default.
• W2063632703 hasConceptScore W2063632703C136571751 @default.
• W2063632703 hasConceptScore W2063632703C137620995 @default.
• W2063632703 hasConceptScore W2063632703C145103041 @default.
• W2063632703 hasConceptScore W2063632703C150194340 @default.
• W2063632703 hasConceptScore W2063632703C153911025 @default.
• W2063632703 hasConceptScore W2063632703C170493617 @default.
• W2063632703 hasConceptScore W2063632703C196843134 @default.
• W2063632703 hasConceptScore W2063632703C205583638 @default.
• W2063632703 hasConceptScore W2063632703C2776735322 @default.
• W2063632703 hasConceptScore W2063632703C2776878037 @default.
• W2063632703 hasConceptScore W2063632703C2779535977 @default.
• W2063632703 hasConceptScore W2063632703C2780915607 @default.
• W2063632703 hasConceptScore W2063632703C54355233 @default.
• W2063632703 hasConceptScore W2063632703C62478195 @default.
• W2063632703 hasConceptScore W2063632703C7876069 @default.
• W2063632703 hasConceptScore W2063632703C83484664 @default.
• W2063632703 hasConceptScore W2063632703C86803240 @default.
• W2063632703 hasConceptScore W2063632703C87073359 @default.
• W2063632703 hasConceptScore W2063632703C95444343 @default.
• W2063632703 hasIssue "1" @default.
• W2063632703 hasLocation W20636327031 @default.

• next