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• W2063639242 startingPage "643" @default.
• W2063639242 abstract "The regulation of the basal forebrain cholinergic system by D1 and D2 dopamine receptors was assessed in the rat using in vivo microdialysis of cortical acetylcholine. The D1 agonist CY 208-243 significantly increased cortical acetylcholine release; in contrast, the D2 agonists quinpirole and (+)-4-propyl-9-hydroxynaphthoxazine were without significant effects. Moreover, when administered in combination with CY 208-243, quinpirole failed to potentiate the D1 agonist-induced increases in cortical acetylcholine release. The non-selective dopamine receptor agonist apomorphine also increased cortical acetylcholine release, and this was completely blocked by the selective D1 receptor antagonist SCH 23390 and slightly, but not significantly attenuated by the D2 antagonist raclopride. The present results indicate that stimulation of D1 receptors activates cortically-projecting cholinergic neurons; however, a minor contribution of D2 receptors cannot be excluded." @default.
• W2063639242 created "2016-06-24" @default.
• W2063639242 creator A5034663097 @default.
• W2063639242 creator A5057307907 @default.
• W2063639242 date "1993-06-01" @default.
• W2063639242 modified "2023-10-16" @default.
• W2063639242 title "Dopaminergic regulation of cortical acetylcholine release: Effects of dopamine receptor agonists" @default.
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• W2063639242 doi "https://doi.org/10.1016/0306-4522(93)90235-8" @default.
• W2063639242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8101359" @default.
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