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- W2063653852 abstract "Heparin sulfate has been shown to both stimulate sperm capacitation and cause decondensation of sperm chromatin. Recent studies have shown that sperm chromatin decondensation following exposure to a low concentration of heparin sulfate is inversely correlated with penetration ability. This study shows that sperm from subfertile patients contain a higher ( p <. 05) concentration of heparin binding sites than sperm from donors of known fertility. No differences were observed in the binding affinity of 3 H-labeled heparin to donor and patient sperm. Binding was specific for sulfated heparin and dextran. FITC-labeled heparin bound to a higher percentage ( p <. 01) of patient sperm (39.6 - 3.1) than donor sperm (12.3 - 1.7). A relationship is demonstrated between heparin binding sites and sperm chromatin decondensation following heparin exposure, both of which are increased in sperm from subfertile men." @default.
- W2063653852 created "2016-06-24" @default.
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- W2063653852 date "2002-01-01" @default.
- W2063653852 modified "2023-10-16" @default.
- W2063653852 title "HEPARIN BINDING SITES ARE PRESENT AT A HIGHER CONCENTRATION ON SPERM OF SUBFERTILE MEN THAN DONORS OF KNOWN FERTILITY" @default.
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- W2063653852 doi "https://doi.org/10.1080/014850102317267463" @default.
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