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- W2063658073 abstract "Interleukin-33 (IL-33) is a member of the IL-1 cytokine family, along with IL-1beta and IL-18. IL-33 binds to its receptor ST2 (IL-1RL1), which is expressed by Th2 cells and by various innate immune cells including mast cells and basophils, in which ST2 and the IL-18 receptor α chain, respectively, are predominant [ [1] Kondo Y. Yoshimoto T. Yasuda K. Futatsugi-Yumikura S. Morimoto M. Hayashi N. et al. Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. Int Immunol. 2008; 20: 791-800 Crossref PubMed Scopus (401) Google Scholar ]. IL-33 stimulates the production of Th2 cytokines by those cells and is involved in various types of inflammation [ [2] Yasuda K. Muto T. Kawagoe T. Matsumoto M. Sasaki Y. Matsushita K. et al. Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice. Proc Natl Acad Sci U S A. 2012; 109: 3451-3456 Crossref PubMed Scopus (255) Google Scholar ]. Recently, we have found that ragweed-induced allergic rhinitis is dependent on IL-33 [ [3] Haenuki Y. Matsushita K. Futatsugi-Yumikura S. Ishii K.J. Kawagoe T. Imoto Y. et al. A critical role of IL-33 in experimental allergic rhinitis. J Allergy Clin Immunol. 2012; 130 (e11): 184-194 Abstract Full Text Full Text PDF PubMed Scopus (159) Google Scholar ] and mast cells are abundant in the dermis of skin-specific IL-33 transgenic mice [ [4] Imai Y. Yasuda K. Sakaguchi Y. Haneda T. Mizutani H. Yoshimoto T. et al. Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice. Proc Natl Acad Sci U S A. 2013; 110: 13921-13926 Crossref PubMed Scopus (313) Google Scholar ]. Those prompted us to elucidate the role of IL-33 in cutaneous immediate-type contact hypersensitivity. In this study, we examined hapten-induced immediate-type contact hypersensitivity in IL-33 knockout (KO) mice." @default.
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- W2063658073 date "2014-05-01" @default.
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- W2063658073 title "Immediate-type contact hypersensitivity is reduced in interleukin-33 knockout mice" @default.
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- W2063658073 doi "https://doi.org/10.1016/j.jdermsci.2014.01.009" @default.
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