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- W2063663400 abstract "Objective: In order to assess the genetic stability of doxorubicin resistance sarcoma S-180R cell linein vivo. Methods: The drug resistant genes and molecules were examined by flow cytometry, Southern blot, Northern blot and RT-PCR. Results: The results showed that drug-efflux in S-180R increased nearly 100-folds, as compared with its parent cells, the rate of half peak width resistant cell/peak high decreased from 0.56 to 0.23 measured by flow cytometry after two years. The mdr1 gene amplified and overexpressed significantly in S-180R and the expression of topoisomerase II α gene decreased remarkably in S-180R. There was no significant different of the MRP expression between S-180R and S-180. Conclusion: These results indicated that drug resistance of S-180R was maintained and also increased. The major mechanism of drug resistance is the amplification and overexpression of mdr1 gene, the decreased expression of topoisomerase II α also contributed to it. So, S-180R is an ideal experimental model for the study of doxorubicin resistance and its reversionin vivo." @default.
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- W2063663400 date "1998-09-01" @default.
- W2063663400 modified "2023-09-27" @default.
- W2063663400 title "Molecular biological evidences for the genetic stability of doxorubicin resistant cell line S-180Rin vivo" @default.
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- W2063663400 doi "https://doi.org/10.1007/bf02948358" @default.
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