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- W2063667079 abstract "In this first reported study of weekly paclitaxel administered as first-line chemotherapy for metastatic breast cancer, paclitaxel 100 mg/m2 was administered in a 1-h infusion on a weekly basis to 35 patients who may previoulsly have received adjuvent chemotherapy(but not taxane-containing regimens), but not for advanced or metastatic disease. A median of 14 infusions per patient was given at a mean delivered dose intensity of 94 mg/m2 per week. In 33 assessable patients, a complete response (CR) was observed in 1 patient and partial responses (PRs) in 12 patients, producing an overall response rate of 40%. Stable disease (SD) was observed in 17 patients, of whom 9 were stabilized for more than 24 weeks. Thus, clinical benefit (CR + PR + SD≥ 24 weeks) was observed in 67% of the patients. Time to progression was 189 days, the duration of response 180 days and overall survival 544 days. Five patients developed grade 3 neutropenia and five patients grade 3 comparable response rates and less toxicity than when the drug is given every three weeks. ." @default.
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- W2063667079 date "2004-03-01" @default.
- W2063667079 modified "2023-10-18" @default.
- W2063667079 title "Weekly one-hour paclitaxel as first-line chemotherapy for metastatic breast cancer" @default.
- W2063667079 doi "https://doi.org/10.1080/02841860310017748" @default.
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