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- W2063669168 abstract "A unique separations chemistry and an automated “generator” have been developed for application of the α-emitting radionuclide 213Bi to cancer therapy. The generator was developed for separation of the short-lived 213Bi (t1/2 = 45.6 min) from the parent radionuclide 225Ac (t1/2 = 10 days), which is separated from 229Th (t1/2 = 7340 yr) and its daughter isotope 225Ra (t1/2 = 14.8 days). The generator requires purified 225Ac and uses an organic anion-exchange system capable of isolating 213Bi from a HCl solution of 225Ac. The anion resin is then washed and stripped of the Bi product using a sodium acetate buffer. This allows direct attachment of 213Bi to modified monoclonal antibodies and other targeting agents for use in patient treatment of cancers such as leukemia. To permit safe and rapid isolation of 213Bi in 1 to >20 mCi quantities, an automated system using sequential flow injection was developed. Successful evaluation of the labeling efficiency of proteins was completed using the separated Bi product." @default.
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- W2063669168 date "2000-07-06" @default.
- W2063669168 modified "2023-09-27" @default.
- W2063669168 title "Development of a Unique Bismuth (Bi-213) Automated Generator for Use in Cancer Therapy" @default.
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- W2063669168 doi "https://doi.org/10.1021/ie990068r" @default.
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