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• W2063670073 abstract "Manganese superoxide dismutase (MnSOD) is a nuclear-encoded and mitochondria-matrix-localized oxidation-reduction (redox) enzyme that regulates cellular redox homeostasis. Cellular redox processes are known to regulate proliferative and quiescent growth states. Therefore, MnSOD and mitochondria-generated reactive oxygen species (ROS) are believed to be critical regulators of quiescent cells' entry into the cell cycle and exit from the proliferative cycle back to the quiescent state.Recent evidence suggests that the intracellular redox environment fluctuates during the cell cycle, shifting toward a more oxidized status during mitosis. MnSOD activity is higher in G0/G1 cells compared with S, G2 and M phases. After cell division, MnSOD activity increases in the G1 phase of the daughter generation. The periodic fluctuation in MnSOD activity during the cell cycle inversely correlates with cellular superoxide levels as well as glucose and oxygen consumption. Based on an inverse correlation between MnSOD activity and glucose consumption during the cell cycle, it is proposed that MnSOD is a central molecular player for the Warburg effect.In general, loss of MnSOD activity results in aberrant proliferation. A better understanding of the MnSOD and mitochondrial ROS-dependent cell cycle processes may lead to novel approaches to overcome aberrant proliferation. Since ROS have both deleterious (pathological) and beneficial (physiological) effects, it is proposed that eustress should be used when discussing ROS processes that regulate normal physiological functions, while oxidative stress should be used to discuss the deleterious effects of ROS." @default.
• W2063670073 created "2016-06-24" @default.
• W2063670073 creator A5036264139 @default.
• W2063670073 creator A5037718853 @default.
• W2063670073 creator A5076756306 @default.
• W2063670073 date "2014-04-01" @default.
• W2063670073 modified "2023-09-27" @default.
• W2063670073 title "Manganese Superoxide Dismutase Regulates a Redox Cycle Within the Cell Cycle" @default.
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• W2063670073 doi "https://doi.org/10.1089/ars.2013.5303" @default.
• W2063670073 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3942678" @default.
• W2063670073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23590434" @default.
• W2063670073 hasPublicationYear "2014" @default.
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