FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063670296> ?p ?o ?g. }

• W2063670296 endingPage "184" @default.
• W2063670296 startingPage "175" @default.
• W2063670296 abstract "Overexpression of genes in production pathways and permanent knockout of genes in competing pathways are often employed to improve production titer and yield in metabolic engineering. However, the deletion of a pathway responsible for growth and cell maintenance has not previously been employed, even if its competition with the production pathway is obvious. In order to optimize intracellular metabolism at each fermentation phase for bacterial growth and production, a methodology employing conditional knockout is required. We constructed a metabolic toggle switch in Escherichia coli as a novel conditional knockout approach and applied it to isopropanol production. The resulting redirection of excess carbon flux caused by interruption of the TCA cycle via switching gltA OFF improved isopropanol production titer and yield up to 3.7 and 3.1 times, respectively. This approach is a useful tool to redirect carbon flux responsible for bacterial growth and/or cell maintenance toward a synthetic production pathway. • A synthetic genetic circuit named “metabolic toggle switch” for the redirection of metabolic flux was constructed in E. coli . • Excess carbon flux in the TCA cycle was redirected toward isopropanol production pathway by metabolic toggle switch. • Using metabolic toggle switch, isopropanol production titer and yield improved up to 3.7 and 3.1 times, respectively." @default.
• W2063670296 created "2016-06-24" @default.
• W2063670296 creator A5054478664 @default.
• W2063670296 creator A5055042870 @default.
• W2063670296 creator A5085539789 @default.
• W2063670296 creator A5086565000 @default.
• W2063670296 creator A5090400392 @default.
• W2063670296 date "2014-05-01" @default.
• W2063670296 modified "2023-09-29" @default.
• W2063670296 title "Metabolic flux redirection from a central metabolic pathway toward a synthetic pathway using a metabolic toggle switch" @default.
• W2063670296 cites W124916304 @default.
• W2063670296 cites W1547106545 @default.
• W2063670296 cites W1583901171 @default.
• W2063670296 cites W1587777700 @default.
• W2063670296 cites W1972549326 @default.
• W2063670296 cites W1989469642 @default.
• W2063670296 cites W1996629685 @default.
• W2063670296 cites W1999912067 @default.
• W2063670296 cites W2001307435 @default.
• W2063670296 cites W2005815224 @default.
• W2063670296 cites W2007686134 @default.
• W2063670296 cites W2016830368 @default.
• W2063670296 cites W2020610175 @default.
• W2063670296 cites W2021933218 @default.
• W2063670296 cites W2022761336 @default.
• W2063670296 cites W2035418452 @default.
• W2063670296 cites W2038922280 @default.
• W2063670296 cites W2039829903 @default.
• W2063670296 cites W2042649558 @default.
• W2063670296 cites W2052362431 @default.
• W2063670296 cites W2054506883 @default.
• W2063670296 cites W2060831068 @default.
• W2063670296 cites W2061548335 @default.
• W2063670296 cites W2073265884 @default.
• W2063670296 cites W2073413292 @default.
• W2063670296 cites W2076647485 @default.
• W2063670296 cites W2084140927 @default.
• W2063670296 cites W2089832080 @default.
• W2063670296 cites W2091304959 @default.
• W2063670296 cites W2098081446 @default.
• W2063670296 cites W2108131456 @default.
• W2063670296 cites W2110384600 @default.
• W2063670296 cites W2110534321 @default.
• W2063670296 cites W2116137883 @default.
• W2063670296 cites W2116918487 @default.
• W2063670296 cites W2132238954 @default.
• W2063670296 cites W2132828256 @default.
• W2063670296 cites W2134759932 @default.
• W2063670296 cites W2136536485 @default.
• W2063670296 cites W2141564052 @default.
• W2063670296 cites W2143626957 @default.
• W2063670296 cites W2148641266 @default.
• W2063670296 cites W2150088285 @default.
• W2063670296 cites W2152572010 @default.
• W2063670296 cites W2154767435 @default.
• W2063670296 cites W2154797402 @default.
• W2063670296 cites W2156964936 @default.
• W2063670296 cites W2162579953 @default.
• W2063670296 cites W2168059482 @default.
• W2063670296 doi "https://doi.org/10.1016/j.ymben.2014.02.008" @default.
• W2063670296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24576819" @default.
• W2063670296 hasPublicationYear "2014" @default.
• W2063670296 type Work @default.
• W2063670296 sameAs 2063670296 @default.
• W2063670296 citedByCount "160" @default.
• W2063670296 countsByYear W20636702962014 @default.
• W2063670296 countsByYear W20636702962015 @default.
• W2063670296 countsByYear W20636702962016 @default.
• W2063670296 countsByYear W20636702962017 @default.
• W2063670296 countsByYear W20636702962018 @default.
• W2063670296 countsByYear W20636702962019 @default.
• W2063670296 countsByYear W20636702962020 @default.
• W2063670296 countsByYear W20636702962021 @default.
• W2063670296 countsByYear W20636702962022 @default.
• W2063670296 countsByYear W20636702962023 @default.
• W2063670296 crossrefType "journal-article" @default.
• W2063670296 hasAuthorship W2063670296A5054478664 @default.
• W2063670296 hasAuthorship W2063670296A5055042870 @default.
• W2063670296 hasAuthorship W2063670296A5085539789 @default.
• W2063670296 hasAuthorship W2063670296A5086565000 @default.
• W2063670296 hasAuthorship W2063670296A5090400392 @default.
• W2063670296 hasConcept C100544194 @default.
• W2063670296 hasConcept C101810790 @default.
• W2063670296 hasConcept C104317684 @default.
• W2063670296 hasConcept C110872660 @default.
• W2063670296 hasConcept C134121241 @default.
• W2063670296 hasConcept C160941953 @default.
• W2063670296 hasConcept C178790620 @default.
• W2063670296 hasConcept C185592680 @default.
• W2063670296 hasConcept C18903297 @default.
• W2063670296 hasConcept C191897082 @default.
• W2063670296 hasConcept C191908910 @default.
• W2063670296 hasConcept C192562407 @default.
• W2063670296 hasConcept C192989942 @default.
• W2063670296 hasConcept C2993678126 @default.
• W2063670296 hasConcept C547475151 @default.
• W2063670296 hasConcept C55493867 @default.
• W2063670296 hasConcept C62231903 @default.

• next