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- W2063671952 abstract "The vertebrate neural crest is a pluripotent cell population that generates a large variety of cell types, including peripheral neurons, cartilage and pigment cells. Mechanisms that control the patterning of the neural crest toward specific cell fates remain only partially understood. Zebrafish homozygous for the sympathetic mutation 1 (sym1) have defects in a subset of neural crest derivatives, such as peripheral neurons, glia and cartilage, but retain normal numbers of melanocytes. The sym1 mutation is a nucleotide deletion that disrupts the forkhead DNA-binding domain of the foxd3 gene, which encodes a conserved winged-helix transcription factor. We show that sym1 mutants have normal numbers of premigratory neural crest cells, but these cells express reduced levels of snai1b and sox10, implicating foxd3 as an essential regulator of these transcription factors in the premigratory neural crest. The onset of neural crest migration is also delayed in sym1 mutants, and there is a reduction in the number of migratory trunk neural crest cells, particularly along the medial migration pathway. TUNEL analysis revealed aberrant apoptosis localized to the hindbrain neural crest at the 15-somite stage, indicating a critical role for foxd3 in the survival of a subpopulation of neural crest cells. These results show that foxd3 selectively specifies premigratory neural crest cells for a neuronal, glial or cartilage fate, by inducing the expression of lineage-associated transcription factors in these cells and regulating their subsequent migration." @default.
- W2063671952 created "2016-06-24" @default.
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- W2063671952 date "2006-04-01" @default.
- W2063671952 modified "2023-10-02" @default.
- W2063671952 title "Zebrafish foxd3 is selectively required for neural crest specification, migration and survival" @default.
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- W2063671952 cites W1888475523 @default.
- W2063671952 cites W1894858966 @default.
- W2063671952 cites W1898326553 @default.
- W2063671952 cites W1920995666 @default.
- W2063671952 cites W1952870715 @default.
- W2063671952 cites W1964079625 @default.
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- W2063671952 cites W1974113993 @default.
- W2063671952 cites W1974723367 @default.
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- W2063671952 cites W1982231225 @default.
- W2063671952 cites W1983049023 @default.
- W2063671952 cites W1983059232 @default.
- W2063671952 cites W1985721503 @default.
- W2063671952 cites W1989897041 @default.
- W2063671952 cites W1990125829 @default.
- W2063671952 cites W1992778213 @default.
- W2063671952 cites W1994015824 @default.
- W2063671952 cites W1995138630 @default.
- W2063671952 cites W1995168697 @default.
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- W2063671952 cites W2001254528 @default.
- W2063671952 cites W2003149480 @default.
- W2063671952 cites W2006081278 @default.
- W2063671952 cites W2010825472 @default.
- W2063671952 cites W2022906661 @default.
- W2063671952 cites W2027059131 @default.
- W2063671952 cites W2028994367 @default.
- W2063671952 cites W2030180991 @default.
- W2063671952 cites W2036159004 @default.
- W2063671952 cites W2040604400 @default.
- W2063671952 cites W2048083836 @default.
- W2063671952 cites W2053387942 @default.
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- W2063671952 cites W2057967850 @default.
- W2063671952 cites W2077406721 @default.
- W2063671952 cites W2077597259 @default.
- W2063671952 cites W2091230390 @default.
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- W2063671952 doi "https://doi.org/10.1016/j.ydbio.2005.12.035" @default.
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