Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063672133> ?p ?o ?g. }
- W2063672133 endingPage "344" @default.
- W2063672133 startingPage "333" @default.
- W2063672133 abstract "Abstract Sensing extracellular milieu is a fundamental requirement of cells. To facilitate and specify sensory reception, mammalian cells develop an antenna‐like structure denoted as the primary cilia. Nearly all interphase and nondividing cells in vertebrates have a single, nonmotile seemingly unspecialized cilium (called a primary cilium). In the central nervous system, astrocytes express primary cilia, but their function in astrocytes has not been examined. Recent studies have shown that primary cilia unite receptors and the machinery of signal‐transduction components, such as Wnt and Hedgehog (Hh) signaling cascades. Although, Hh signaling cascades are known to be activated in various cells during development, their physiological functions in the adult nervous system, especially in glial cells, are still unknown. In this study, we reveal that glial primary cilia receive the Hh signal and regulate the survival of astrocytes under stressed conditions such as starvation. Interestingly, increased astrocyte survival was reversed by knockdown of Ift20 , which is one of the main components for building primary cilia. These results collectively indicate that the activation of Hh signaling in the primary cilia plays an important role in the survival of astrocytes under stressed conditions. © 2010 Wiley‐Liss, Inc." @default.
- W2063672133 created "2016-06-24" @default.
- W2063672133 creator A5005018064 @default.
- W2063672133 creator A5006314872 @default.
- W2063672133 creator A5044214575 @default.
- W2063672133 date "2010-12-01" @default.
- W2063672133 modified "2023-10-16" @default.
- W2063672133 title "Signaling through the primary cilium affects glial cell survival under a stressed environment" @default.
- W2063672133 cites W1967546149 @default.
- W2063672133 cites W1970264904 @default.
- W2063672133 cites W1974601240 @default.
- W2063672133 cites W1977969186 @default.
- W2063672133 cites W1982055359 @default.
- W2063672133 cites W1983688519 @default.
- W2063672133 cites W1985143102 @default.
- W2063672133 cites W1993028307 @default.
- W2063672133 cites W1993465232 @default.
- W2063672133 cites W1996907803 @default.
- W2063672133 cites W1999537835 @default.
- W2063672133 cites W2011409454 @default.
- W2063672133 cites W2012162930 @default.
- W2063672133 cites W2013900815 @default.
- W2063672133 cites W2014064761 @default.
- W2063672133 cites W2015678476 @default.
- W2063672133 cites W2032792789 @default.
- W2063672133 cites W2043547083 @default.
- W2063672133 cites W2043772793 @default.
- W2063672133 cites W2051167451 @default.
- W2063672133 cites W2051953163 @default.
- W2063672133 cites W2066480724 @default.
- W2063672133 cites W2068687154 @default.
- W2063672133 cites W2070184849 @default.
- W2063672133 cites W2073496230 @default.
- W2063672133 cites W2077266233 @default.
- W2063672133 cites W2077614233 @default.
- W2063672133 cites W2079100427 @default.
- W2063672133 cites W2083988049 @default.
- W2063672133 cites W2085356690 @default.
- W2063672133 cites W2086618165 @default.
- W2063672133 cites W2091684557 @default.
- W2063672133 cites W2094100088 @default.
- W2063672133 cites W2095575759 @default.
- W2063672133 cites W2096961422 @default.
- W2063672133 cites W2112331825 @default.
- W2063672133 cites W2113283367 @default.
- W2063672133 cites W2124981525 @default.
- W2063672133 cites W2126134918 @default.
- W2063672133 cites W2126569376 @default.
- W2063672133 cites W2131977398 @default.
- W2063672133 cites W2135979384 @default.
- W2063672133 cites W2137691824 @default.
- W2063672133 cites W2150164927 @default.
- W2063672133 cites W2153136319 @default.
- W2063672133 cites W2161919807 @default.
- W2063672133 cites W2171652940 @default.
- W2063672133 cites W2288125743 @default.
- W2063672133 cites W4211143281 @default.
- W2063672133 doi "https://doi.org/10.1002/glia.21105" @default.
- W2063672133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21125655" @default.
- W2063672133 hasPublicationYear "2010" @default.
- W2063672133 type Work @default.
- W2063672133 sameAs 2063672133 @default.
- W2063672133 citedByCount "34" @default.
- W2063672133 countsByYear W20636721332012 @default.
- W2063672133 countsByYear W20636721332013 @default.
- W2063672133 countsByYear W20636721332014 @default.
- W2063672133 countsByYear W20636721332015 @default.
- W2063672133 countsByYear W20636721332016 @default.
- W2063672133 countsByYear W20636721332017 @default.
- W2063672133 countsByYear W20636721332018 @default.
- W2063672133 countsByYear W20636721332019 @default.
- W2063672133 countsByYear W20636721332020 @default.
- W2063672133 countsByYear W20636721332021 @default.
- W2063672133 countsByYear W20636721332022 @default.
- W2063672133 countsByYear W20636721332023 @default.
- W2063672133 crossrefType "journal-article" @default.
- W2063672133 hasAuthorship W2063672133A5005018064 @default.
- W2063672133 hasAuthorship W2063672133A5006314872 @default.
- W2063672133 hasAuthorship W2063672133A5044214575 @default.
- W2063672133 hasConcept C100094513 @default.
- W2063672133 hasConcept C109523444 @default.
- W2063672133 hasConcept C137620995 @default.
- W2063672133 hasConcept C167814343 @default.
- W2063672133 hasConcept C169760540 @default.
- W2063672133 hasConcept C195267511 @default.
- W2063672133 hasConcept C2777542381 @default.
- W2063672133 hasConcept C2910422434 @default.
- W2063672133 hasConcept C529278444 @default.
- W2063672133 hasConcept C54355233 @default.
- W2063672133 hasConcept C55728118 @default.
- W2063672133 hasConcept C62478195 @default.
- W2063672133 hasConcept C86803240 @default.
- W2063672133 hasConcept C95444343 @default.
- W2063672133 hasConceptScore W2063672133C100094513 @default.
- W2063672133 hasConceptScore W2063672133C109523444 @default.
- W2063672133 hasConceptScore W2063672133C137620995 @default.
- W2063672133 hasConceptScore W2063672133C167814343 @default.
- W2063672133 hasConceptScore W2063672133C169760540 @default.