Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063674711> ?p ?o ?g. }
- W2063674711 endingPage "2691" @default.
- W2063674711 startingPage "2681" @default.
- W2063674711 abstract "Transport kinetics have been examined in erythrocyte anion transporter AE1 that has been chemically modified to convert glutamate 681 to an alcohol (E681OH AE1). Outward conductive Cl− flux in E681OH AE1 is inhibited by removal of extracellular Cl−; this effect is the opposite of that in native AE1 and is consistent with coupled electrogenic 2:1 Cl−/Cl− exchange. A second Cl− binding/transport site is also suggested by the characteristics of S35O42− flux in E681OH AE1: bilateral and cis Cl−, which are normally inhibitory, accelerate S35O42− flux. These effects would be expected if Cl− binds to a second transport site on SO42−-loaded E681OH AE1, thereby allowing Cl−/SO42− cotransport. Alternatively, the data can be explained without proposing Cl−/SO42− cotransport if the rate-limiting event for S35O42−/SO42− exchange is external SO42− release, and the binding of external Cl− accelerates SO42− release. With either interpretation, these data indicate that E681OH AE1 has a binding/transport site for Cl− that is distinct from the main transport site. The effects of graded modification of E681 or inhibition by H2DIDS are consistent with the idea that the new Cl− binding site is on the same E681OH-modified subunit of the AE1 dimer as the normal transport site." @default.
- W2063674711 created "2016-06-24" @default.
- W2063674711 creator A5057756099 @default.
- W2063674711 date "2005-04-01" @default.
- W2063674711 modified "2023-10-12" @default.
- W2063674711 title "Evidence for a Second Binding/Transport Site for Chloride in Erythrocyte Anion Transporter AE1 Modified at Glutamate 681" @default.
- W2063674711 cites W112121826 @default.
- W2063674711 cites W129717176 @default.
- W2063674711 cites W1481256749 @default.
- W2063674711 cites W1551636999 @default.
- W2063674711 cites W1559922603 @default.
- W2063674711 cites W1560584977 @default.
- W2063674711 cites W1581243106 @default.
- W2063674711 cites W1648849217 @default.
- W2063674711 cites W181761884 @default.
- W2063674711 cites W1975405396 @default.
- W2063674711 cites W1975887425 @default.
- W2063674711 cites W1976843559 @default.
- W2063674711 cites W1980811217 @default.
- W2063674711 cites W1985383659 @default.
- W2063674711 cites W1987629548 @default.
- W2063674711 cites W1988654956 @default.
- W2063674711 cites W1994088425 @default.
- W2063674711 cites W2001373658 @default.
- W2063674711 cites W2004793189 @default.
- W2063674711 cites W2005501525 @default.
- W2063674711 cites W2009145474 @default.
- W2063674711 cites W2011044229 @default.
- W2063674711 cites W2013595691 @default.
- W2063674711 cites W2032567864 @default.
- W2063674711 cites W2043156718 @default.
- W2063674711 cites W2073879684 @default.
- W2063674711 cites W2080865165 @default.
- W2063674711 cites W2082230027 @default.
- W2063674711 cites W2082323294 @default.
- W2063674711 cites W2082972585 @default.
- W2063674711 cites W2084340106 @default.
- W2063674711 cites W2097400197 @default.
- W2063674711 cites W2097607770 @default.
- W2063674711 cites W2101310148 @default.
- W2063674711 cites W2122530523 @default.
- W2063674711 cites W2124928237 @default.
- W2063674711 cites W2126210530 @default.
- W2063674711 cites W2146856227 @default.
- W2063674711 cites W2147142035 @default.
- W2063674711 cites W2150339615 @default.
- W2063674711 cites W2164770545 @default.
- W2063674711 cites W2164797647 @default.
- W2063674711 cites W2289833142 @default.
- W2063674711 cites W2410263143 @default.
- W2063674711 cites W2437989835 @default.
- W2063674711 cites W2921033738 @default.
- W2063674711 cites W2980054351 @default.
- W2063674711 cites W75960386 @default.
- W2063674711 cites W81363032 @default.
- W2063674711 doi "https://doi.org/10.1529/biophysj.104.056812" @default.
- W2063674711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1305364" @default.
- W2063674711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15653731" @default.
- W2063674711 hasPublicationYear "2005" @default.
- W2063674711 type Work @default.
- W2063674711 sameAs 2063674711 @default.
- W2063674711 citedByCount "20" @default.
- W2063674711 countsByYear W20636747112013 @default.
- W2063674711 countsByYear W20636747112015 @default.
- W2063674711 countsByYear W20636747112016 @default.
- W2063674711 countsByYear W20636747112017 @default.
- W2063674711 countsByYear W20636747112018 @default.
- W2063674711 countsByYear W20636747112020 @default.
- W2063674711 countsByYear W20636747112021 @default.
- W2063674711 crossrefType "journal-article" @default.
- W2063674711 hasAuthorship W2063674711A5057756099 @default.
- W2063674711 hasBestOaLocation W20636747111 @default.
- W2063674711 hasConcept C104317684 @default.
- W2063674711 hasConcept C107824862 @default.
- W2063674711 hasConcept C121332964 @default.
- W2063674711 hasConcept C12554922 @default.
- W2063674711 hasConcept C148898269 @default.
- W2063674711 hasConcept C149011108 @default.
- W2063674711 hasConcept C178790620 @default.
- W2063674711 hasConcept C185592680 @default.
- W2063674711 hasConcept C188053792 @default.
- W2063674711 hasConcept C2776589458 @default.
- W2063674711 hasConcept C2779546866 @default.
- W2063674711 hasConcept C2993443003 @default.
- W2063674711 hasConcept C41625074 @default.
- W2063674711 hasConcept C537181965 @default.
- W2063674711 hasConcept C55493867 @default.
- W2063674711 hasConcept C62520636 @default.
- W2063674711 hasConcept C68709404 @default.
- W2063674711 hasConcept C71240020 @default.
- W2063674711 hasConcept C86803240 @default.
- W2063674711 hasConcept C96267730 @default.
- W2063674711 hasConcept C99975950 @default.
- W2063674711 hasConceptScore W2063674711C104317684 @default.
- W2063674711 hasConceptScore W2063674711C107824862 @default.
- W2063674711 hasConceptScore W2063674711C121332964 @default.
- W2063674711 hasConceptScore W2063674711C12554922 @default.
- W2063674711 hasConceptScore W2063674711C148898269 @default.