FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063676190> ?p ?o ?g. }

• W2063676190 endingPage "10729" @default.
• W2063676190 startingPage "10729" @default.
• W2063676190 abstract "The interplay between inflammation and cancer progression is a growing area of research. A combination of clinical, epidemiological, and basic science investigations indicate that there is a relationship between inflammatory changes in the pancreas and neoplastic progression. Diets high in ω-6 polyunsaturated fatty acids provide increased substrate for arachidonic acid metabolism by cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) to form eicosanoids. These eicosanoids directly contribute to pancreatic cancer cell proliferation. Both COX-2 and 5-LOX are upregulated in multiple cancer types, including pancreatic cancer. In vitro studies using pancreatic cancer cell lines have demonstrated upregulation of COX-2 and 5-LOX at both the mRNA and protein levels. When COX-2 and 5-LOX are blocked via a variety of mechanisms, cancer cell proliferation is abrogated both in vitro and in vivo. The mechanism of COX-2 has been shown to include effects on apoptosis as well as angiogenesis. 5-LOX has been implicated in apoptosis. The use of COX-2 and 5-LOX inhibitors in clinical studies in patients with pancreatic cancer has been limited. Patient enrollment has been restricted to those with advanced disease which makes evaluation of these drugs as chemopreventive agents difficult. COX-2 and 5-LOX expression have been shown to be present during the early neoplastic changes of pancreatic cancer, well before progression to invasive disease. This indicates that the ideal role for these interventions is early in the disease process as preventive agents, perhaps in patients with chronic pancreatitis or hereditary pancreatitis." @default.
• W2063676190 created "2016-06-24" @default.
• W2063676190 creator A5017375931 @default.
• W2063676190 creator A5032770196 @default.
• W2063676190 creator A5064900293 @default.
• W2063676190 date "2014-01-01" @default.
• W2063676190 modified "2023-09-27" @default.
• W2063676190 title "Involvement of eicosanoids in the pathogenesis of pancreatic cancer: The roles of cyclooxygenase-2 and 5-lipoxygenase" @default.
• W2063676190 cites W1516766006 @default.
• W2063676190 cites W1606163850 @default.
• W2063676190 cites W1964099867 @default.
• W2063676190 cites W1966894597 @default.
• W2063676190 cites W1973431219 @default.
• W2063676190 cites W1973434151 @default.
• W2063676190 cites W1986170048 @default.
• W2063676190 cites W1990404670 @default.
• W2063676190 cites W1998855245 @default.
• W2063676190 cites W2000920285 @default.
• W2063676190 cites W2004351423 @default.
• W2063676190 cites W2005771165 @default.
• W2063676190 cites W2006658102 @default.
• W2063676190 cites W2007187686 @default.
• W2063676190 cites W2010061213 @default.
• W2063676190 cites W2014271351 @default.
• W2063676190 cites W2017816682 @default.
• W2063676190 cites W2019266913 @default.
• W2063676190 cites W2023213942 @default.
• W2063676190 cites W2023460263 @default.
• W2063676190 cites W2023724559 @default.
• W2063676190 cites W2034398502 @default.
• W2063676190 cites W2035412612 @default.
• W2063676190 cites W2039854803 @default.
• W2063676190 cites W2041676299 @default.
• W2063676190 cites W2051686420 @default.
• W2063676190 cites W2052505697 @default.
• W2063676190 cites W2052561723 @default.
• W2063676190 cites W2058031342 @default.
• W2063676190 cites W2060176852 @default.
• W2063676190 cites W2060425936 @default.
• W2063676190 cites W2063110913 @default.
• W2063676190 cites W2066474674 @default.
• W2063676190 cites W2071978906 @default.
• W2063676190 cites W2072000048 @default.
• W2063676190 cites W2077647756 @default.
• W2063676190 cites W2078886883 @default.
• W2063676190 cites W2082764531 @default.
• W2063676190 cites W2083238673 @default.
• W2063676190 cites W2086173889 @default.
• W2063676190 cites W2087127619 @default.
• W2063676190 cites W2089225273 @default.
• W2063676190 cites W2096377599 @default.
• W2063676190 cites W2097498461 @default.
• W2063676190 cites W2104416279 @default.
• W2063676190 cites W2105524540 @default.
• W2063676190 cites W2108404067 @default.
• W2063676190 cites W2112963192 @default.
• W2063676190 cites W2116554142 @default.
• W2063676190 cites W2126868151 @default.
• W2063676190 cites W2127607312 @default.
• W2063676190 cites W2128519797 @default.
• W2063676190 cites W2136383268 @default.
• W2063676190 cites W2136990999 @default.
• W2063676190 cites W2137045595 @default.
• W2063676190 cites W2137892434 @default.
• W2063676190 cites W2142202628 @default.
• W2063676190 cites W2144073669 @default.
• W2063676190 cites W2145248653 @default.
• W2063676190 cites W2146647609 @default.
• W2063676190 cites W2150379602 @default.
• W2063676190 cites W2151924547 @default.
• W2063676190 cites W2152557257 @default.
• W2063676190 cites W2157612047 @default.
• W2063676190 cites W2157759704 @default.
• W2063676190 cites W2160234181 @default.
• W2063676190 cites W2163919118 @default.
• W2063676190 cites W2166770565 @default.
• W2063676190 cites W2170795266 @default.
• W2063676190 cites W2249183791 @default.
• W2063676190 cites W2318156113 @default.
• W2063676190 cites W2332325099 @default.
• W2063676190 cites W4244578979 @default.
• W2063676190 cites W4254329876 @default.
• W2063676190 cites W4321317624 @default.
• W2063676190 doi "https://doi.org/10.3748/wjg.v20.i31.10729" @default.
• W2063676190 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4138453" @default.
• W2063676190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25152576" @default.
• W2063676190 hasPublicationYear "2014" @default.
• W2063676190 type Work @default.
• W2063676190 sameAs 2063676190 @default.
• W2063676190 citedByCount "51" @default.
• W2063676190 countsByYear W20636761902015 @default.
• W2063676190 countsByYear W20636761902016 @default.
• W2063676190 countsByYear W20636761902017 @default.
• W2063676190 countsByYear W20636761902018 @default.
• W2063676190 countsByYear W20636761902019 @default.
• W2063676190 countsByYear W20636761902020 @default.
• W2063676190 countsByYear W20636761902021 @default.
• W2063676190 countsByYear W20636761902022 @default.

• next