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- W2063676210 abstract "Abstract 1. 1. The general hypothesis that glucocorticoids may act on certain extrahepatic tissues via a direct, rapid inhibition of glucose utilization, has been tested using incubated suspensions of rat-thymus cells. 2. 2. It has been found that net glucose uptake by cells obtained from rats injected 2 h previously with cortisol (approx. 1 mg per 100 g rat wt.) is significantly lower than that of control cells. 3. 3. Cortisol in vitro, at concentrations down to 10−7M, significantly decreases net glucose uptake by such cell preparations during the first hour of incubation, and at 10−6M (the only concentration tested) decreases the incorporation of leucine into protein during the second hour. Deoxycorticosterone is less active than cortisol with respect to inhibition of both glucose uptake and amino acid incorporation. 4. 4. These findings are taken to show that a direct, rapid physiological action of glucocorticoids is to decrease glucose uptake by thymus tissue. 5. 5. From the results of incubations with various concentrations of glucose, it appears that the inhibition of amino acid incorporation produced by cortisol is not simply a consequence of decreased availability of glucose to the cell." @default.
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- W2063676210 date "1964-10-01" @default.
- W2063676210 modified "2023-09-27" @default.
- W2063676210 title "Effect of glucocorticoids in vivo and in vitro on net glucose uptake and amino acid incorporation by rat-thymus cells" @default.
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- W2063676210 doi "https://doi.org/10.1016/0304-4165(64)90269-7" @default.
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