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- W2063676586 abstract "Purpose of review Filamentous fungal infections due to rare opportunistic moulds can be transmitted with an allograft. However, epidemiologic and clinical characteristics of donor-derived filamentous fungal infections (DDFFIs) in transplant recipients are poorly understood. Hence, the aim of this article is to describe donor-related risk factors, clinical presentation, graft and recipient outcomes associated with DDFFIs. Recent findings To date, 23 cases of donor-derived opportunistic filamentous fungal infections have been reported; a majority (91%) occurred in kidney transplant recipients. Aspergillus spp. was the most common organism (71%). Risk factors for DDFFIs include immunosuppressive state of the donor (transplant recipients serving as organ donors), near-drowning events, and transplant-tourism practices. DDFFIs manifested as vascular complications related to graft vasculature (65%), allograft dysfunction (43%) and unexplained febrile illness (39%) in the recipient. Rates of graft loss and overall mortality were 83 and 17%, respectively. Summary Donor-transmitted filamentous mycoses have a unique spectrum of illness and clinical settings under which transmission occurs. Prompt recognition, early surgical intervention and specific antifungal therapy are necessary for achieving optimal graft and recipient outcomes." @default.
- W2063676586 created "2016-06-24" @default.
- W2063676586 creator A5006120495 @default.
- W2063676586 creator A5079624082 @default.
- W2063676586 date "2013-08-01" @default.
- W2063676586 modified "2023-09-30" @default.
- W2063676586 title "Donor-derived filamentous fungal infections in solid organ transplant recipients" @default.
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- W2063676586 doi "https://doi.org/10.1097/qco.0b013e3283630e4d" @default.
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