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• W2063677029 abstract "The retinoblastoma tumor suppressor protein (RB) is inactivated in a majority of cancers. RB restricts cell proliferation by inhibiting the E2F family of transcription factors. The current model for RB/E2F function describes its role in regulating transcription at gene promoters. Whether the RB or E2F proteins might play a role in gene expression beyond transcription initiation is not well known. This review describes evidence that points to a novel role for the RB/E2F network in the regulation of RNA processing, and we propose a model as a framework for future research. The elucidation of a novel role of RB in RNA processing will have a profound impact on our understanding of the role of this tumor suppressor family in cell and developmental biology." @default.
• W2063677029 created "2016-06-24" @default.
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• W2063677029 date "2009-07-01" @default.
• W2063677029 modified "2023-10-18" @default.
• W2063677029 title "The RB/E2F pathway and regulation of RNA processing" @default.
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• W2063677029 doi "https://doi.org/10.1016/j.bbrc.2009.04.107" @default.
• W2063677029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3926418" @default.
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