FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063696945> ?p ?o ?g. }

• W2063696945 endingPage "190" @default.
• W2063696945 startingPage "180" @default.
• W2063696945 abstract "Oxidative damage represents the most significant insult to organisms because of continuous production of the reactive oxygen species (ROS) in vivo. Oxidative damage in DNA, a critical target of ROS, is repaired primarily via the base excision repair (BER) pathway which appears to be the simplest among the three excision repair pathways. However, it is now evident that although BER can be carried with four or five enzymes in vitro, a large number of proteins, including some required for nucleotide excision repair (NER), are needed for in vivo repair of oxidative damage. Furthermore, BER in transcribed vs. nontranscribed DNA regions requires distinct sets of proteins, as in the case of NER. We propose an additional complexity in repair of replicating vs. nonreplicating DNA. Unlike DNA bulky adducts, the oxidized base lesions could be incorporated in the nascent DNA strand, repair of which may share components of the mismatch repair process. Distinct enzyme specificities are thus warranted for repair of lesions in the parental vs. nascent DNA strand. Repair synthesis may be carried out by DNA polymerase beta or replicative polymerases delta and epsilon. Thus, multiple subpathways are needed for repairing oxidative DNA damage, and the pathway decision may require coordination of the successive steps in repair. Such coordination includes transfer of the product of a DNA glycosylase to AP-endonuclease, the next enzyme in the pathway. Interactions among proteins in the pathway may also reflect such coordination, characterization of which should help elucidate these subpathways and their in vivo regulation." @default.
• W2063696945 created "2016-06-24" @default.
• W2063696945 creator A5024316557 @default.
• W2063696945 creator A5061702912 @default.
• W2063696945 creator A5077467093 @default.
• W2063696945 creator A5082029120 @default.
• W2063696945 date "2001-01-01" @default.
• W2063696945 modified "2023-10-18" @default.
• W2063696945 title "Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage" @default.
• W2063696945 cites W1516609571 @default.
• W2063696945 cites W1545021361 @default.
• W2063696945 cites W1560861994 @default.
• W2063696945 cites W1577831872 @default.
• W2063696945 cites W1587686680 @default.
• W2063696945 cites W1593685083 @default.
• W2063696945 cites W1647238192 @default.
• W2063696945 cites W167055734 @default.
• W2063696945 cites W1966318682 @default.
• W2063696945 cites W1968895302 @default.
• W2063696945 cites W1971602039 @default.
• W2063696945 cites W1974585689 @default.
• W2063696945 cites W1975225200 @default.
• W2063696945 cites W1977988390 @default.
• W2063696945 cites W1978197786 @default.
• W2063696945 cites W1984290310 @default.
• W2063696945 cites W1984353960 @default.
• W2063696945 cites W1986606105 @default.
• W2063696945 cites W1987430471 @default.
• W2063696945 cites W1992514146 @default.
• W2063696945 cites W2000479074 @default.
• W2063696945 cites W2000605935 @default.
• W2063696945 cites W2004864721 @default.
• W2063696945 cites W2007629066 @default.
• W2063696945 cites W2007998684 @default.
• W2063696945 cites W2010992218 @default.
• W2063696945 cites W2012300945 @default.
• W2063696945 cites W2017626786 @default.
• W2063696945 cites W2019777050 @default.
• W2063696945 cites W2023990700 @default.
• W2063696945 cites W2029243559 @default.
• W2063696945 cites W2038392802 @default.
• W2063696945 cites W2038964655 @default.
• W2063696945 cites W2040135708 @default.
• W2063696945 cites W2042723688 @default.
• W2063696945 cites W2048527989 @default.
• W2063696945 cites W2049122340 @default.
• W2063696945 cites W2059901912 @default.
• W2063696945 cites W2064477710 @default.
• W2063696945 cites W2064538331 @default.
• W2063696945 cites W2067552277 @default.
• W2063696945 cites W2068373542 @default.
• W2063696945 cites W2077634990 @default.
• W2063696945 cites W2078424943 @default.
• W2063696945 cites W2083902090 @default.
• W2063696945 cites W2091403301 @default.
• W2063696945 cites W2092147306 @default.
• W2063696945 cites W2111736994 @default.
• W2063696945 cites W2120902002 @default.
• W2063696945 cites W2126784037 @default.
• W2063696945 cites W2131668983 @default.
• W2063696945 cites W2134316981 @default.
• W2063696945 cites W2152116092 @default.
• W2063696945 cites W2154690470 @default.
• W2063696945 cites W2154828075 @default.
• W2063696945 cites W2161596679 @default.
• W2063696945 cites W2163886554 @default.
• W2063696945 cites W2168882862 @default.
• W2063696945 cites W2169939490 @default.
• W2063696945 cites W2437313603 @default.
• W2063696945 cites W958327846 @default.
• W2063696945 doi "https://doi.org/10.1002/em.1070" @default.
• W2063696945 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4927302" @default.
• W2063696945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11746753" @default.
• W2063696945 hasPublicationYear "2001" @default.
• W2063696945 type Work @default.
• W2063696945 sameAs 2063696945 @default.
• W2063696945 citedByCount "126" @default.
• W2063696945 countsByYear W20636969452012 @default.
• W2063696945 countsByYear W20636969452013 @default.
• W2063696945 countsByYear W20636969452014 @default.
• W2063696945 countsByYear W20636969452015 @default.
• W2063696945 countsByYear W20636969452016 @default.
• W2063696945 countsByYear W20636969452017 @default.
• W2063696945 countsByYear W20636969452018 @default.
• W2063696945 countsByYear W20636969452019 @default.
• W2063696945 countsByYear W20636969452020 @default.
• W2063696945 countsByYear W20636969452021 @default.
• W2063696945 countsByYear W20636969452022 @default.
• W2063696945 countsByYear W20636969452023 @default.
• W2063696945 crossrefType "journal-article" @default.
• W2063696945 hasAuthorship W2063696945A5024316557 @default.
• W2063696945 hasAuthorship W2063696945A5061702912 @default.
• W2063696945 hasAuthorship W2063696945A5077467093 @default.
• W2063696945 hasAuthorship W2063696945A5082029120 @default.
• W2063696945 hasBestOaLocation W20636969452 @default.
• W2063696945 hasConcept C1009745 @default.
• W2063696945 hasConcept C104451858 @default.
• W2063696945 hasConcept C134935766 @default.

• next