FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063700636> ?p ?o ?g. }

• W2063700636 endingPage "3958" @default.
• W2063700636 startingPage "3945" @default.
• W2063700636 abstract "The p53 protein has been a subject of intense research interest since its discovery as about 50% of human cancers carry p53 mutations. Mutations in the p53 gene are the most frequent genetic lesions in breast cancers suggesting a critical role of p53 in breast cancer development, growth and chemosensitivity. This report describes the derivation and characterization of MCF-7As53, an isogenic cell line derived from MCF-7 breast carcinoma cells in which p53 was abrogated by antisense p53 cDNA. Similar to MCF-7 and simultaneously selected hygromycin resistant MCF-7H cells, MCF-7As53 cells have consistent basal epithelial phenotype, morphology, and estrogen receptor expression levels at normal growth conditions. Present work documents investigation of molecular variations, growth kinetics, and cell cycle related studies in relation to absence of wild-type p53 protein and its transactivation potential as well. Even though wild-type tumor suppressor p53 is an activator of cell growth arrest and apoptosis-mediator genes such as p21, Bax, and GADD45 in MCF-7As53 cells, no alterations in expression levels of these genes were detected. The doubling time of these cells decreased due to depletion of G0/G1 cell phase because of constitutive activation of Akt and increase in cyclin D1 protein levels. This proliferative property was abrogated by wortmannin, an inhibitor of PI3-K/Akt signaling pathway. Therefore this p53 null cell line indicates that p53 is an indispensable component of cellular signaling system which is regulated by caveolin-1 expression, involving Akt activation and increase in cyclin D1, thereby promoting proliferation of breast cancer cells." @default.
• W2063700636 created "2016-06-24" @default.
• W2063700636 creator A5048246370 @default.
• W2063700636 creator A5063424506 @default.
• W2063700636 creator A5079333280 @default.
• W2063700636 creator A5079831605 @default.
• W2063700636 date "2007-11-01" @default.
• W2063700636 modified "2023-09-28" @default.
• W2063700636 title "Abrogation of p53 by its antisense in MCF-7 breast carcinoma cells increases cyclin D1 via activation of Akt and promotion of cell proliferation" @default.
• W2063700636 cites W1506576730 @default.
• W2063700636 cites W1529944274 @default.
• W2063700636 cites W1927337580 @default.
• W2063700636 cites W1967880683 @default.
• W2063700636 cites W1968840150 @default.
• W2063700636 cites W1970731925 @default.
• W2063700636 cites W1980025278 @default.
• W2063700636 cites W1989261260 @default.
• W2063700636 cites W1991494214 @default.
• W2063700636 cites W1994411455 @default.
• W2063700636 cites W1997264713 @default.
• W2063700636 cites W2010012275 @default.
• W2063700636 cites W2015519364 @default.
• W2063700636 cites W2021009690 @default.
• W2063700636 cites W2026960700 @default.
• W2063700636 cites W2028799611 @default.
• W2063700636 cites W2031855484 @default.
• W2063700636 cites W2033489089 @default.
• W2063700636 cites W2035258932 @default.
• W2063700636 cites W2037089629 @default.
• W2063700636 cites W2038189029 @default.
• W2063700636 cites W2045086385 @default.
• W2063700636 cites W2067751798 @default.
• W2063700636 cites W2080125477 @default.
• W2063700636 cites W2082245177 @default.
• W2063700636 cites W2082979850 @default.
• W2063700636 cites W2084602777 @default.
• W2063700636 cites W2086368252 @default.
• W2063700636 cites W2089449927 @default.
• W2063700636 cites W2090025028 @default.
• W2063700636 cites W2090647015 @default.
• W2063700636 cites W2095330943 @default.
• W2063700636 cites W2101858607 @default.
• W2063700636 cites W2106888057 @default.
• W2063700636 cites W2108172661 @default.
• W2063700636 cites W2108482850 @default.
• W2063700636 cites W2115913881 @default.
• W2063700636 cites W2117299292 @default.
• W2063700636 cites W2122122875 @default.
• W2063700636 cites W2128060680 @default.
• W2063700636 cites W2130704889 @default.
• W2063700636 cites W2133963443 @default.
• W2063700636 cites W2135709160 @default.
• W2063700636 cites W2142105072 @default.
• W2063700636 cites W2143324424 @default.
• W2063700636 cites W2144932698 @default.
• W2063700636 cites W2148958834 @default.
• W2063700636 cites W2160269020 @default.
• W2063700636 cites W2166029855 @default.
• W2063700636 cites W2167841373 @default.
• W2063700636 cites W2168636998 @default.
• W2063700636 cites W2172064884 @default.
• W2063700636 cites W2282528059 @default.
• W2063700636 cites W2318098003 @default.
• W2063700636 cites W3027123504 @default.
• W2063700636 cites W4250777910 @default.
• W2063700636 doi "https://doi.org/10.1016/j.yexcr.2007.08.022" @default.
• W2063700636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17935714" @default.
• W2063700636 hasPublicationYear "2007" @default.
• W2063700636 type Work @default.
• W2063700636 sameAs 2063700636 @default.
• W2063700636 citedByCount "13" @default.
• W2063700636 countsByYear W20637006362012 @default.
• W2063700636 countsByYear W20637006362013 @default.
• W2063700636 countsByYear W20637006362015 @default.
• W2063700636 countsByYear W20637006362017 @default.
• W2063700636 crossrefType "journal-article" @default.
• W2063700636 hasAuthorship W2063700636A5048246370 @default.
• W2063700636 hasAuthorship W2063700636A5063424506 @default.
• W2063700636 hasAuthorship W2063700636A5079333280 @default.
• W2063700636 hasAuthorship W2063700636A5079831605 @default.
• W2063700636 hasConcept C109541995 @default.
• W2063700636 hasConcept C121608353 @default.
• W2063700636 hasConcept C1491633281 @default.
• W2063700636 hasConcept C153911025 @default.
• W2063700636 hasConcept C199835354 @default.
• W2063700636 hasConcept C29537977 @default.
• W2063700636 hasConcept C2994423619 @default.
• W2063700636 hasConcept C502942594 @default.
• W2063700636 hasConcept C54355233 @default.
• W2063700636 hasConcept C62112901 @default.
• W2063700636 hasConcept C62478195 @default.
• W2063700636 hasConcept C75217442 @default.
• W2063700636 hasConcept C86554907 @default.
• W2063700636 hasConcept C86803240 @default.
• W2063700636 hasConcept C95444343 @default.
• W2063700636 hasConcept C96232424 @default.
• W2063700636 hasConceptScore W2063700636C109541995 @default.
• W2063700636 hasConceptScore W2063700636C121608353 @default.

• next