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• W2063701534 startingPage "3" @default.
• W2063701534 abstract "Severely septic patients continue to experience excessive morbidity and mortality despite recent advances in critical care. Although significant resources have been invested in new treatments, almost all have failed to improve outcomes. An improved understanding of sepsis pathophysiology, including the complex interactions between inflammatory, coagulation, and fibrinolytic systems, has accelerated the development of novel treatments. Recombinant human activated protein C (rhAPC), or drotrecogin alfa (activated) (DAA), is currently the only US Food and Drug Administration (FDA)-approved medicine for the treatment of severe sepsis, and only in patients with a high risk of death. This review will discuss the treatment of severe sepsis, focusing on recent discoveries and unresolved questions about DAA's optimal use. Increasing pharmacological experience has generated enthusiasm for investigating medicines already approved for other indications as treatments for severe sepsis. Replacement doses of hydrocortisone and vasopressin may reduce mortality and improve hypotension, respectively, in a subgroup of patients with catecholamine-refractory septic shock. In addition to discussing these new indications, this review will detail the provocative preliminary data from four promising treatments, including two novel modalities: antagonizing high mobility group box protein and inhibiting tissue factor (TF). Observational data from the uncontrolled administration of heparin or statins in septic patients will also be reviewed." @default.
• W2063701534 created "2016-06-24" @default.
• W2063701534 creator A5049402910 @default.
• W2063701534 date "2006-01-01" @default.
• W2063701534 modified "2023-10-18" @default.
• W2063701534 title "Treatment of severe sepsis: where next? Current and future treatment approaches after the introduction of drotrecogin alfa" @default.
• W2063701534 cites W1214608791 @default.
• W2063701534 cites W132642117 @default.
• W2063701534 cites W1481234838 @default.
• W2063701534 cites W1541957757 @default.
• W2063701534 cites W1567817045 @default.
• W2063701534 cites W1582902340 @default.
• W2063701534 cites W1602148448 @default.
• W2063701534 cites W167520159 @default.
• W2063701534 cites W178589946 @default.
• W2063701534 cites W1818157388 @default.
• W2063701534 cites W1914155470 @default.
• W2063701534 cites W1928206214 @default.
• W2063701534 cites W1963410819 @default.
• W2063701534 cites W1963660953 @default.
• W2063701534 cites W1964091764 @default.
• W2063701534 cites W1966797205 @default.
• W2063701534 cites W1966875441 @default.
• W2063701534 cites W1968590837 @default.
• W2063701534 cites W1968891062 @default.
• W2063701534 cites W1977166847 @default.
• W2063701534 cites W1977905350 @default.
• W2063701534 cites W1979115593 @default.
• W2063701534 cites W1983379130 @default.
• W2063701534 cites W1984592139 @default.
• W2063701534 cites W1984854267 @default.
• W2063701534 cites W1986539575 @default.
• W2063701534 cites W1992311120 @default.
• W2063701534 cites W1993033081 @default.
• W2063701534 cites W1994190235 @default.
• W2063701534 cites W1996110514 @default.
• W2063701534 cites W1997054462 @default.
• W2063701534 cites W2002278814 @default.
• W2063701534 cites W2002359689 @default.
• W2063701534 cites W2004095374 @default.
• W2063701534 cites W2004266769 @default.
• W2063701534 cites W2005515164 @default.
• W2063701534 cites W2005970543 @default.
• W2063701534 cites W2006957433 @default.
• W2063701534 cites W2009975233 @default.
• W2063701534 cites W2014616632 @default.
• W2063701534 cites W2015082788 @default.
• W2063701534 cites W2015178989 @default.
• W2063701534 cites W2015222304 @default.
• W2063701534 cites W2016062235 @default.
• W2063701534 cites W2017885661 @default.
• W2063701534 cites W2018032641 @default.
• W2063701534 cites W2019043807 @default.
• W2063701534 cites W2024014178 @default.
• W2063701534 cites W2025960306 @default.
• W2063701534 cites W2026623381 @default.
• W2063701534 cites W2028294482 @default.
• W2063701534 cites W2028546766 @default.
• W2063701534 cites W2029068688 @default.
• W2063701534 cites W2029491963 @default.
• W2063701534 cites W2031323861 @default.
• W2063701534 cites W2031558790 @default.
• W2063701534 cites W2033968552 @default.
• W2063701534 cites W2034878459 @default.
• W2063701534 cites W2035233871 @default.
• W2063701534 cites W2035917666 @default.
• W2063701534 cites W2036498909 @default.
• W2063701534 cites W2036787121 @default.
• W2063701534 cites W2037872670 @default.
• W2063701534 cites W2038546354 @default.
• W2063701534 cites W2040968233 @default.
• W2063701534 cites W2042023287 @default.
• W2063701534 cites W2042268246 @default.
• W2063701534 cites W2042532113 @default.
• W2063701534 cites W2042928998 @default.
• W2063701534 cites W2044142824 @default.
• W2063701534 cites W2044322051 @default.
• W2063701534 cites W2049536129 @default.
• W2063701534 cites W2049927822 @default.
• W2063701534 cites W2050280222 @default.
• W2063701534 cites W2050392973 @default.
• W2063701534 cites W2053140252 @default.
• W2063701534 cites W2055670597 @default.
• W2063701534 cites W2058346805 @default.
• W2063701534 cites W2059217150 @default.
• W2063701534 cites W2060762130 @default.
• W2063701534 cites W2062054105 @default.
• W2063701534 cites W2062253917 @default.
• W2063701534 cites W2064909686 @default.
• W2063701534 cites W2065322500 @default.
• W2063701534 cites W2068518430 @default.
• W2063701534 cites W2072208656 @default.
• W2063701534 cites W2074503728 @default.
• W2063701534 cites W2074975933 @default.
• W2063701534 cites W2075276667 @default.
• W2063701534 cites W2076243684 @default.
• W2063701534 cites W2085060329 @default.
• W2063701534 cites W2086476972 @default.

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