Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063702960> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2063702960 endingPage "335" @default.
- W2063702960 startingPage "329" @default.
- W2063702960 abstract "This report reviews 48 patients who from 1979 to 1994 were treated at the Norwegian Radium Hospital for newly diagnosed noncerebral extragonadal malignant germ cell tumour (EGGCT). Based on histology and/or serum tumour markers, 12 patients had a seminoma and 36 a non-seminoma. At diagnosis, 33 and 15 patients were classified as having abdominal and mediastinal EGGCT respectively. At the time of diagnosis 13 patients, all with non-seminomatous tumours, had metastases to bone, liver or brain. One patient with abdominal seminoma was cured by radiotherapy alone, whereas cisplatin-based chemotherapy (with or without surgery) was planned in the 47 remaining patients. Twenty-seven out of 42 patients receiving four or more chemotherapy cycles were rendered tumour free by induction chemotherapy, including 5 of the 13 patients with extralymphatic non-pulmonal disease. An additional tumour-free patient died of septicaemia after only two cycles of chemotherapy. Late relapses (after > 2 years) were observed in three patients, and a testicular primary was diagnosed during follow-up in three cases. Seven patients died of treatment-related complications, five of these because of neutropenic septicaemia. The median age of these patients was 52 years compared with 35 years in the remaining 41 patients (P < 0.05). The 5-year overall survival for all 48 patients was 60% (95% CI 46-74%) [cancer-specific 5-year survival 71% (95% CI 50-92%)]. EGGCT is a potentially curable disease, even in patients with very advanced disease. Special attention should, however, be devoted to patients above the age of 40 years because of an increased risk of treatment-related side-effects. Late relapses and the subsequent development of testicular tumours indicate the need for long-term follow-up." @default.
- W2063702960 created "2016-06-24" @default.
- W2063702960 creator A5006978535 @default.
- W2063702960 creator A5029584479 @default.
- W2063702960 creator A5031447233 @default.
- W2063702960 creator A5056318188 @default.
- W2063702960 creator A5062805582 @default.
- W2063702960 creator A5084372136 @default.
- W2063702960 date "1998-01-01" @default.
- W2063702960 modified "2023-10-14" @default.
- W2063702960 title "Treatment and outcome of patients with extragonadal germ cell tumours - the Norwegian Radium Hospital's experience 1979-94" @default.
- W2063702960 cites W1852554427 @default.
- W2063702960 cites W1901841823 @default.
- W2063702960 cites W1969626236 @default.
- W2063702960 cites W1976217486 @default.
- W2063702960 cites W2012218081 @default.
- W2063702960 cites W2012796096 @default.
- W2063702960 cites W2024526415 @default.
- W2063702960 cites W2036729799 @default.
- W2063702960 cites W2039924984 @default.
- W2063702960 cites W2101458725 @default.
- W2063702960 cites W2118974991 @default.
- W2063702960 cites W2126996880 @default.
- W2063702960 cites W2279427630 @default.
- W2063702960 cites W2344068579 @default.
- W2063702960 cites W2404720624 @default.
- W2063702960 cites W2414358077 @default.
- W2063702960 doi "https://doi.org/10.1038/bjc.1998.51" @default.
- W2063702960 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2151244" @default.
- W2063702960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9461006" @default.
- W2063702960 hasPublicationYear "1998" @default.
- W2063702960 type Work @default.
- W2063702960 sameAs 2063702960 @default.
- W2063702960 citedByCount "29" @default.
- W2063702960 countsByYear W20637029602012 @default.
- W2063702960 countsByYear W20637029602015 @default.
- W2063702960 countsByYear W20637029602016 @default.
- W2063702960 countsByYear W20637029602017 @default.
- W2063702960 countsByYear W20637029602019 @default.
- W2063702960 crossrefType "journal-article" @default.
- W2063702960 hasAuthorship W2063702960A5006978535 @default.
- W2063702960 hasAuthorship W2063702960A5029584479 @default.
- W2063702960 hasAuthorship W2063702960A5031447233 @default.
- W2063702960 hasAuthorship W2063702960A5056318188 @default.
- W2063702960 hasAuthorship W2063702960A5062805582 @default.
- W2063702960 hasAuthorship W2063702960A5084372136 @default.
- W2063702960 hasBestOaLocation W20637029602 @default.
- W2063702960 hasConcept C126322002 @default.
- W2063702960 hasConcept C141071460 @default.
- W2063702960 hasConcept C2776252090 @default.
- W2063702960 hasConcept C2776694085 @default.
- W2063702960 hasConcept C2776938808 @default.
- W2063702960 hasConcept C2778074268 @default.
- W2063702960 hasConcept C2778324911 @default.
- W2063702960 hasConcept C509974204 @default.
- W2063702960 hasConcept C71924100 @default.
- W2063702960 hasConceptScore W2063702960C126322002 @default.
- W2063702960 hasConceptScore W2063702960C141071460 @default.
- W2063702960 hasConceptScore W2063702960C2776252090 @default.
- W2063702960 hasConceptScore W2063702960C2776694085 @default.
- W2063702960 hasConceptScore W2063702960C2776938808 @default.
- W2063702960 hasConceptScore W2063702960C2778074268 @default.
- W2063702960 hasConceptScore W2063702960C2778324911 @default.
- W2063702960 hasConceptScore W2063702960C509974204 @default.
- W2063702960 hasConceptScore W2063702960C71924100 @default.
- W2063702960 hasIssue "2" @default.
- W2063702960 hasLocation W20637029601 @default.
- W2063702960 hasLocation W20637029602 @default.
- W2063702960 hasLocation W20637029603 @default.
- W2063702960 hasLocation W20637029604 @default.
- W2063702960 hasOpenAccess W2063702960 @default.
- W2063702960 hasPrimaryLocation W20637029601 @default.
- W2063702960 hasRelatedWork W1993965140 @default.
- W2063702960 hasRelatedWork W2000973645 @default.
- W2063702960 hasRelatedWork W2038242919 @default.
- W2063702960 hasRelatedWork W2089609493 @default.
- W2063702960 hasRelatedWork W2153554853 @default.
- W2063702960 hasRelatedWork W2349204430 @default.
- W2063702960 hasRelatedWork W2387970634 @default.
- W2063702960 hasRelatedWork W2409579930 @default.
- W2063702960 hasRelatedWork W2417555288 @default.
- W2063702960 hasRelatedWork W2417719052 @default.
- W2063702960 hasVolume "77" @default.
- W2063702960 isParatext "false" @default.
- W2063702960 isRetracted "false" @default.
- W2063702960 magId "2063702960" @default.
- W2063702960 workType "article" @default.