Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063706408> ?p ?o ?g. }
- W2063706408 endingPage "103" @default.
- W2063706408 startingPage "76" @default.
- W2063706408 abstract "Oxysterols are oxidized 27-carbon cholesterol derivatives or by-products of cholesterol biosynthesis, with a spectrum of biologic activities. Several oxysterols have cytotoxic and pro-apoptotic activities, the ability to interfere with the lateral domain organization, and packing of membrane lipids. These properties may account for their suggested roles in the pathology of diseases such as atherosclerosis, age-onset macular degeneration and Alzheimer’s disease. Oxysterols also have the capacity to induce inflammatory responses and play roles in cell differentiation processes. The functions of oxysterols as intermediates in the synthesis of bile acids and steroid hormones, and as readily transportable forms of sterol, are well established. Furthermore, their actions as endogenous regulators of gene expression in lipid metabolism via liver X receptors and the Insig (insulin-induced gene) proteins have been investigated in detail. The cytoplasmic oxysterol-binding protein (OSBP) homologues form a group of oxysterol/cholesterol sensors that has recently attracted a lot of attention. However, their mode of action is, as yet, poorly understood. Retinoic acid receptor-related orphan receptors (ROR) α and γ, and Epstein-Barr virus induced gene 2 (EBI2) have been identified as novel oxysterol receptors, revealing new physiologic oxysterol effector mechanisms in development, metabolism, and immunity, and evoking enhanced interest in these compounds in the field of biomedicine." @default.
- W2063706408 created "2016-06-24" @default.
- W2063706408 creator A5043375101 @default.
- W2063706408 creator A5075525029 @default.
- W2063706408 creator A5087516364 @default.
- W2063706408 date "2012-02-15" @default.
- W2063706408 modified "2023-10-15" @default.
- W2063706408 title "Oxysterols and Their Cellular Effectors" @default.
- W2063706408 cites W1480307543 @default.
- W2063706408 cites W1500619872 @default.
- W2063706408 cites W1580279589 @default.
- W2063706408 cites W1583827678 @default.
- W2063706408 cites W1862564406 @default.
- W2063706408 cites W1904828024 @default.
- W2063706408 cites W1963635975 @default.
- W2063706408 cites W1966456662 @default.
- W2063706408 cites W1969050289 @default.
- W2063706408 cites W1971263149 @default.
- W2063706408 cites W1972163077 @default.
- W2063706408 cites W1972407010 @default.
- W2063706408 cites W1975689661 @default.
- W2063706408 cites W1979624565 @default.
- W2063706408 cites W1981143815 @default.
- W2063706408 cites W1990501023 @default.
- W2063706408 cites W1990632046 @default.
- W2063706408 cites W1993083084 @default.
- W2063706408 cites W1993223367 @default.
- W2063706408 cites W1993720376 @default.
- W2063706408 cites W1995424431 @default.
- W2063706408 cites W1996168740 @default.
- W2063706408 cites W1997142270 @default.
- W2063706408 cites W1998477311 @default.
- W2063706408 cites W1998624303 @default.
- W2063706408 cites W1998971316 @default.
- W2063706408 cites W2000252988 @default.
- W2063706408 cites W2001079924 @default.
- W2063706408 cites W2004148253 @default.
- W2063706408 cites W2006050842 @default.
- W2063706408 cites W2008757142 @default.
- W2063706408 cites W2008793342 @default.
- W2063706408 cites W2010762097 @default.
- W2063706408 cites W2010903584 @default.
- W2063706408 cites W2011123221 @default.
- W2063706408 cites W2012859794 @default.
- W2063706408 cites W2016870402 @default.
- W2063706408 cites W2017506227 @default.
- W2063706408 cites W2017661157 @default.
- W2063706408 cites W2018078607 @default.
- W2063706408 cites W2019796661 @default.
- W2063706408 cites W2021926309 @default.
- W2063706408 cites W2023202905 @default.
- W2063706408 cites W2024692118 @default.
- W2063706408 cites W2024905084 @default.
- W2063706408 cites W2029472328 @default.
- W2063706408 cites W2030150229 @default.
- W2063706408 cites W2031727704 @default.
- W2063706408 cites W2033414404 @default.
- W2063706408 cites W2035829439 @default.
- W2063706408 cites W2038363528 @default.
- W2063706408 cites W2040429499 @default.
- W2063706408 cites W2041205811 @default.
- W2063706408 cites W2041596767 @default.
- W2063706408 cites W2047904155 @default.
- W2063706408 cites W2048883263 @default.
- W2063706408 cites W2050108739 @default.
- W2063706408 cites W2050373296 @default.
- W2063706408 cites W2050412627 @default.
- W2063706408 cites W2051676732 @default.
- W2063706408 cites W2052304001 @default.
- W2063706408 cites W2052735059 @default.
- W2063706408 cites W2053131885 @default.
- W2063706408 cites W2054295214 @default.
- W2063706408 cites W2056141575 @default.
- W2063706408 cites W2056927666 @default.
- W2063706408 cites W2057086747 @default.
- W2063706408 cites W2057680047 @default.
- W2063706408 cites W2059770288 @default.
- W2063706408 cites W2061415248 @default.
- W2063706408 cites W2061450441 @default.
- W2063706408 cites W2063072550 @default.
- W2063706408 cites W2063471837 @default.
- W2063706408 cites W2064875837 @default.
- W2063706408 cites W2064892346 @default.
- W2063706408 cites W2065957795 @default.
- W2063706408 cites W2066135657 @default.
- W2063706408 cites W2066763353 @default.
- W2063706408 cites W2073449051 @default.
- W2063706408 cites W2073905908 @default.
- W2063706408 cites W2075108450 @default.
- W2063706408 cites W2076554898 @default.
- W2063706408 cites W2079763440 @default.
- W2063706408 cites W2080121847 @default.
- W2063706408 cites W2081370792 @default.
- W2063706408 cites W2081597336 @default.
- W2063706408 cites W2083701433 @default.
- W2063706408 cites W2083956020 @default.
- W2063706408 cites W2083957918 @default.
- W2063706408 cites W2084248110 @default.