FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063707658> ?p ?o ?g. }

• W2063707658 endingPage "10427" @default.
• W2063707658 startingPage "10417" @default.
• W2063707658 abstract "Patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer derive significant clinical benefit from treatment with the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. Secondary EGFR mutations such as EGFR T790M commonly lead to resistance to these agents, limiting their long-term efficacy. Irreversible EGFR inhibitors such as CL-387,785 can overcome resistance and are in clinical development, yet acquired resistance against these agents is anticipated. We carried out a cell-based, in vitro random mutagenesis screen to identify EGFR mutations that confer resistance to CL-387,785 using T790M-mutant H1975 lung adenocarcinoma cells. Mutations at several residues occurred repeatedly leading to functional resistance to CL-387,785. These variants showed uninhibited cell growth, reduced apoptosis, and persistent EGFR activation in the presence of CL-387,785 as compared with parental H1975 cells, thus confirming their role in resistance. A screen of alternative agents showed that both an alternative EGFR inhibitor and a cyclin-dependent kinase 4 inhibitor led to significant inhibition of cell growth of the resistant mutants, suggestive of potential alternative treatment strategies. These results identify novel mutations mediating resistance to irreversible EGFR inhibitors and reveal alternative strategies to overcome or prevent the development of resistance in EGFR-mutant non-small cell lung cancers." @default.
• W2063707658 created "2016-06-24" @default.
• W2063707658 creator A5019506336 @default.
• W2063707658 creator A5023903377 @default.
• W2063707658 creator A5024341499 @default.
• W2063707658 creator A5033841005 @default.
• W2063707658 creator A5035198996 @default.
• W2063707658 creator A5036587861 @default.
• W2063707658 creator A5062505521 @default.
• W2063707658 creator A5065813780 @default.
• W2063707658 creator A5081356537 @default.
• W2063707658 date "2007-11-01" @default.
• W2063707658 modified "2023-10-14" @default.
• W2063707658 title "Resistance to an Irreversible Epidermal Growth Factor Receptor (EGFR) Inhibitor in EGFR-Mutant Lung Cancer Reveals Novel Treatment Strategies" @default.
• W2063707658 cites W1965871143 @default.
• W2063707658 cites W1972132555 @default.
• W2063707658 cites W1989410548 @default.
• W2063707658 cites W1990222254 @default.
• W2063707658 cites W1998281478 @default.
• W2063707658 cites W1998971866 @default.
• W2063707658 cites W2000489928 @default.
• W2063707658 cites W2001829888 @default.
• W2063707658 cites W2002937040 @default.
• W2063707658 cites W2003984225 @default.
• W2063707658 cites W2011924961 @default.
• W2063707658 cites W2013083986 @default.
• W2063707658 cites W2015616444 @default.
• W2063707658 cites W2043696829 @default.
• W2063707658 cites W2050954424 @default.
• W2063707658 cites W2051750973 @default.
• W2063707658 cites W2062766483 @default.
• W2063707658 cites W2065521652 @default.
• W2063707658 cites W2072140252 @default.
• W2063707658 cites W2093922887 @default.
• W2063707658 cites W2096786080 @default.
• W2063707658 cites W2100794900 @default.
• W2063707658 cites W2111109297 @default.
• W2063707658 cites W2114195503 @default.
• W2063707658 cites W2116398087 @default.
• W2063707658 cites W2127732584 @default.
• W2063707658 cites W2131351052 @default.
• W2063707658 cites W2133051701 @default.
• W2063707658 cites W2138297714 @default.
• W2063707658 cites W2139236349 @default.
• W2063707658 cites W2143877481 @default.
• W2063707658 cites W2161821474 @default.
• W2063707658 cites W2168841302 @default.
• W2063707658 cites W2169816570 @default.
• W2063707658 cites W2170257914 @default.
• W2063707658 doi "https://doi.org/10.1158/0008-5472.can-07-1248" @default.
• W2063707658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17974985" @default.
• W2063707658 hasPublicationYear "2007" @default.
• W2063707658 type Work @default.
• W2063707658 sameAs 2063707658 @default.
• W2063707658 citedByCount "57" @default.
• W2063707658 countsByYear W20637076582012 @default.
• W2063707658 countsByYear W20637076582013 @default.
• W2063707658 countsByYear W20637076582014 @default.
• W2063707658 countsByYear W20637076582015 @default.
• W2063707658 countsByYear W20637076582017 @default.
• W2063707658 countsByYear W20637076582018 @default.
• W2063707658 countsByYear W20637076582019 @default.
• W2063707658 countsByYear W20637076582020 @default.
• W2063707658 countsByYear W20637076582021 @default.
• W2063707658 countsByYear W20637076582022 @default.
• W2063707658 countsByYear W20637076582023 @default.
• W2063707658 crossrefType "journal-article" @default.
• W2063707658 hasAuthorship W2063707658A5019506336 @default.
• W2063707658 hasAuthorship W2063707658A5023903377 @default.
• W2063707658 hasAuthorship W2063707658A5024341499 @default.
• W2063707658 hasAuthorship W2063707658A5033841005 @default.
• W2063707658 hasAuthorship W2063707658A5035198996 @default.
• W2063707658 hasAuthorship W2063707658A5036587861 @default.
• W2063707658 hasAuthorship W2063707658A5062505521 @default.
• W2063707658 hasAuthorship W2063707658A5065813780 @default.
• W2063707658 hasAuthorship W2063707658A5081356537 @default.
• W2063707658 hasBestOaLocation W20637076581 @default.
• W2063707658 hasConcept C104317684 @default.
• W2063707658 hasConcept C121608353 @default.
• W2063707658 hasConcept C126322002 @default.
• W2063707658 hasConcept C143065580 @default.
• W2063707658 hasConcept C170493617 @default.
• W2063707658 hasConcept C2776256026 @default.
• W2063707658 hasConcept C2776362946 @default.
• W2063707658 hasConcept C2777506169 @default.
• W2063707658 hasConcept C2777930144 @default.
• W2063707658 hasConcept C2778087573 @default.
• W2063707658 hasConcept C2779438470 @default.
• W2063707658 hasConcept C2780580887 @default.
• W2063707658 hasConcept C2780586478 @default.
• W2063707658 hasConcept C2909325608 @default.
• W2063707658 hasConcept C42362537 @default.
• W2063707658 hasConcept C502942594 @default.
• W2063707658 hasConcept C55493867 @default.
• W2063707658 hasConcept C62112901 @default.
• W2063707658 hasConcept C71924100 @default.
• W2063707658 hasConcept C86803240 @default.
• W2063707658 hasConceptScore W2063707658C104317684 @default.

• next