FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063710318> ?p ?o ?g. }

• W2063710318 endingPage "623" @default.
• W2063710318 startingPage "614" @default.
• W2063710318 abstract "Cyclooxygenase-2 (COX-2) is overexpressed in colon tumors. Its main product is the immunosuppressive prostaglandin PGE2 that aids tumor immune escape. In this study, we analyzed mechanisms of action of the COX-2 inhibitor rofecoxib on the immune response to colorectal cancer in an animal model. The murine colorectal cancer cell line MC26, and splenocytes from BALB/c mice immune to irradiated MC26 cells, were incubated with rofecoxib or PGE2. In MC26 cells, 100 nM rofecoxib caused a complete abrogation of PGE2 production and inhibited cell proliferation. Splenocytes from tumor immune mice showed a 300% (P<0.01) increase in proliferation in response to irradiated MC26 cells, amplified to 450% (P<0.01) by 1 microM rofecoxib (n=3). MC26 cells incubated with 1 microM rofecoxib showed increased gene expression of CCL3, CCL5, and CCL20 (P<0.01). enzyme-linked immunosorbent assay tests also showed increased production of CCL5 and CCL20 (P<0.01). PGE2 reversed this effect causing a 40% reduction in chemokine gene expression (n=3). In contrast, splenocytes from naive BALB/c mice stimulated with irradiated MC26 cells had only a marginal chemokine response to rofecoxib. PGE2 caused a 50% down-regulation of CCL5 and CCL20 at the gene level (n=2) and 30% and 40% reduction of CCL3, CCL4, CCL5, and CCL20 at the protein level (n=2). Hence rofecoxib has a 2-fold effect upon the immune response to MC26 cells, by enhancing production of chemokines chemotactic for dendritic cells and also reducing PGE2-mediated inhibition of lymphoproliferation. Together, these may be sufficient for an effective TH1-mediated antitumor response. Rofecoxib may have potential as an addition to existing immunotherapy strategies." @default.
• W2063710318 created "2016-06-24" @default.
• W2063710318 creator A5004365508 @default.
• W2063710318 creator A5049110134 @default.
• W2063710318 creator A5082951688 @default.
• W2063710318 creator A5083037743 @default.
• W2063710318 date "2007-09-01" @default.
• W2063710318 modified "2023-09-26" @default.
• W2063710318 title "Rofecoxib has Different Effects on Chemokine Production in Colorectal Cancer Cells and Tumor Immune Splenocytes" @default.
• W2063710318 cites W1524737589 @default.
• W2063710318 cites W1534766853 @default.
• W2063710318 cites W1602835962 @default.
• W2063710318 cites W1603690031 @default.
• W2063710318 cites W1648593433 @default.
• W2063710318 cites W1964006242 @default.
• W2063710318 cites W1978201079 @default.
• W2063710318 cites W1981662925 @default.
• W2063710318 cites W2012810767 @default.
• W2063710318 cites W2014392976 @default.
• W2063710318 cites W2027344845 @default.
• W2063710318 cites W2030279593 @default.
• W2063710318 cites W2053315646 @default.
• W2063710318 cites W2058118671 @default.
• W2063710318 cites W2058461395 @default.
• W2063710318 cites W2075256580 @default.
• W2063710318 cites W2078036862 @default.
• W2063710318 cites W2082990300 @default.
• W2063710318 cites W2083362070 @default.
• W2063710318 cites W2087568024 @default.
• W2063710318 cites W2107560602 @default.
• W2063710318 cites W2116102795 @default.
• W2063710318 cites W2127558096 @default.
• W2063710318 cites W2137375900 @default.
• W2063710318 cites W2138877935 @default.
• W2063710318 cites W2142881330 @default.
• W2063710318 cites W2151089147 @default.
• W2063710318 cites W2151539516 @default.
• W2063710318 cites W2169198863 @default.
• W2063710318 cites W2317981107 @default.
• W2063710318 cites W305594902 @default.
• W2063710318 cites W1980858407 @default.
• W2063710318 doi "https://doi.org/10.1097/cji.0b013e31805ca039" @default.
• W2063710318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17667525" @default.
• W2063710318 hasPublicationYear "2007" @default.
• W2063710318 type Work @default.
• W2063710318 sameAs 2063710318 @default.
• W2063710318 citedByCount "7" @default.
• W2063710318 countsByYear W20637103182012 @default.
• W2063710318 countsByYear W20637103182015 @default.
• W2063710318 countsByYear W20637103182018 @default.
• W2063710318 countsByYear W20637103182020 @default.
• W2063710318 countsByYear W20637103182022 @default.
• W2063710318 crossrefType "journal-article" @default.
• W2063710318 hasAuthorship W2063710318A5004365508 @default.
• W2063710318 hasAuthorship W2063710318A5049110134 @default.
• W2063710318 hasAuthorship W2063710318A5082951688 @default.
• W2063710318 hasAuthorship W2063710318A5083037743 @default.
• W2063710318 hasConcept C116484652 @default.
• W2063710318 hasConcept C12823836 @default.
• W2063710318 hasConcept C13373296 @default.
• W2063710318 hasConcept C143172330 @default.
• W2063710318 hasConcept C153911025 @default.
• W2063710318 hasConcept C181199279 @default.
• W2063710318 hasConcept C185592680 @default.
• W2063710318 hasConcept C203014093 @default.
• W2063710318 hasConcept C2776090121 @default.
• W2063710318 hasConcept C2778582115 @default.
• W2063710318 hasConcept C2779689624 @default.
• W2063710318 hasConcept C502942594 @default.
• W2063710318 hasConcept C55493867 @default.
• W2063710318 hasConcept C71924100 @default.
• W2063710318 hasConcept C79484868 @default.
• W2063710318 hasConcept C83360876 @default.
• W2063710318 hasConcept C86803240 @default.
• W2063710318 hasConcept C8891405 @default.
• W2063710318 hasConceptScore W2063710318C116484652 @default.
• W2063710318 hasConceptScore W2063710318C12823836 @default.
• W2063710318 hasConceptScore W2063710318C13373296 @default.
• W2063710318 hasConceptScore W2063710318C143172330 @default.
• W2063710318 hasConceptScore W2063710318C153911025 @default.
• W2063710318 hasConceptScore W2063710318C181199279 @default.
• W2063710318 hasConceptScore W2063710318C185592680 @default.
• W2063710318 hasConceptScore W2063710318C203014093 @default.
• W2063710318 hasConceptScore W2063710318C2776090121 @default.
• W2063710318 hasConceptScore W2063710318C2778582115 @default.
• W2063710318 hasConceptScore W2063710318C2779689624 @default.
• W2063710318 hasConceptScore W2063710318C502942594 @default.
• W2063710318 hasConceptScore W2063710318C55493867 @default.
• W2063710318 hasConceptScore W2063710318C71924100 @default.
• W2063710318 hasConceptScore W2063710318C79484868 @default.
• W2063710318 hasConceptScore W2063710318C83360876 @default.
• W2063710318 hasConceptScore W2063710318C86803240 @default.
• W2063710318 hasConceptScore W2063710318C8891405 @default.
• W2063710318 hasIssue "6" @default.
• W2063710318 hasLocation W20637103181 @default.
• W2063710318 hasLocation W20637103182 @default.
• W2063710318 hasOpenAccess W2063710318 @default.
• W2063710318 hasPrimaryLocation W20637103181 @default.

• next