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- W2063717811 abstract "We sought to determine the optimum estradiol valerate-medroxyprogesterone acetate regimens for efficacy and safety.We performed a 24-month, randomized, double-blind phase II study. Four hundred nineteen women who were postmenopausal for at least 3 years were placed in six parallel treatment groups and received 1 or 2 mg estradiol valerate with either 2.5 or 5 mg medroxyprogesterone acetate. In two groups the dose of estradiol valerate was increased from 1 to 2 mg estradiol valerate after 6 months.A marked improvement of climacteric symptoms was observed, and most women had no bleeding even during the first 3 months of treatment. The best bleeding pattern was achieved with 1 mg estradiol valerate and 2.5 or 5 mg medroxyprogesterone acetate, and in most groups the bleeding pattern improved over time. No cases of hyperplasia were observed.All regimens alleviated climacteric symptoms and provided excellent bleeding control, even during the early weeks of treatment. A choice of various dose combinations offers flexibility of dosing, thus enabling therapy to be tailored to the needs of individual women." @default.
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- W2063717811 date "2000-03-01" @default.
- W2063717811 modified "2023-09-26" @default.
- W2063717811 title "Optimizing continuous-combined hormone replacement therapy for postmenopausal women: A comparison of six different treatment regimens" @default.
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- W2063717811 doi "https://doi.org/10.1067/mob.2000.104767" @default.
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