FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063722263> ?p ?o ?g. }

• W2063722263 endingPage "689" @default.
• W2063722263 startingPage "684" @default.
• W2063722263 abstract "The neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) modulates inflammation by inhibiting production of proinflammatory cytokines. Using a plasmid vector encoding alpha-MSH, we examined whether autocrine alpha-MSH inhibits activation of the nuclear transcription factor NF-kappaB, a factor that is essential to expression of proinflammatory cytokines, in human glioma cells (A-172). Electrophoretic mobility shift assays of nuclear extracts demonstrated that NF-kappaB activation induced by lipopolysaccharide was inhibited in glioma cells transfected with alpha-MSH vector. Western blot analysis revealed that this inhibition was linked to preservation of expression of IkappaBalpha protein. Chloramphenicol acetyltransferase assay indicated that NF-kappaB-dependent reporter gene expression was suppressed in A-172 cells transfected with alpha-MSH vector. Finally, fluorescence staining confirmed that A-172 cells bear alpha-MSH receptors. The findings are consistent with the idea that, in central nervous system (CNS) inflammation, autocrine alpha-MSH exerts anti-inflammatory actions via modulation of NF-kappaB activation by preservation of IkappaBalpha protein. Based on this action of the peptide, it should be possible to treat neurodegenerative disease, stroke, encephalitis, trauma, and other CNS disorders that have an inflammatory component through gene therapy with alpha-MSH vector." @default.
• W2063722263 created "2016-06-24" @default.
• W2063722263 creator A5001186893 @default.
• W2063722263 creator A5050446452 @default.
• W2063722263 creator A5051458827 @default.
• W2063722263 creator A5072415289 @default.
• W2063722263 creator A5084178973 @default.
• W2063722263 date "1999-11-12" @default.
• W2063722263 modified "2023-10-18" @default.
• W2063722263 title "Autocrine α‐melanocyte‐stimulating hormone inhibits NF‐κB activation in human glioma" @default.
• W2063722263 cites W1486150850 @default.
• W2063722263 cites W1496877897 @default.
• W2063722263 cites W1549372716 @default.
• W2063722263 cites W1562925757 @default.
• W2063722263 cites W1566308385 @default.
• W2063722263 cites W1868478050 @default.
• W2063722263 cites W1904705252 @default.
• W2063722263 cites W1925917964 @default.
• W2063722263 cites W1968987342 @default.
• W2063722263 cites W1970951686 @default.
• W2063722263 cites W1973223056 @default.
• W2063722263 cites W1979420492 @default.
• W2063722263 cites W1984219903 @default.
• W2063722263 cites W1991634993 @default.
• W2063722263 cites W2001870469 @default.
• W2063722263 cites W2010343759 @default.
• W2063722263 cites W2011445167 @default.
• W2063722263 cites W2012983715 @default.
• W2063722263 cites W2015690288 @default.
• W2063722263 cites W2018999902 @default.
• W2063722263 cites W2030305474 @default.
• W2063722263 cites W2040957577 @default.
• W2063722263 cites W2041238959 @default.
• W2063722263 cites W2043138452 @default.
• W2063722263 cites W2052893447 @default.
• W2063722263 cites W2057093252 @default.
• W2063722263 cites W2070853191 @default.
• W2063722263 cites W207397168 @default.
• W2063722263 cites W2076651424 @default.
• W2063722263 cites W2089478514 @default.
• W2063722263 cites W2090930997 @default.
• W2063722263 cites W2102838769 @default.
• W2063722263 cites W2133982451 @default.
• W2063722263 cites W2140660632 @default.
• W2063722263 cites W2140846345 @default.
• W2063722263 cites W2144969564 @default.
• W2063722263 cites W2151892297 @default.
• W2063722263 cites W2162440323 @default.
• W2063722263 cites W2165065437 @default.
• W2063722263 cites W2166781237 @default.
• W2063722263 cites W2187195571 @default.
• W2063722263 cites W4297581650 @default.
• W2063722263 cites W4313333804 @default.
• W2063722263 doi "https://doi.org/10.1002/(sici)1097-4547(19991201)58:5<684::aid-jnr9>3.0.co;2-#" @default.
• W2063722263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10561696" @default.
• W2063722263 hasPublicationYear "1999" @default.
• W2063722263 type Work @default.
• W2063722263 sameAs 2063722263 @default.
• W2063722263 citedByCount "13" @default.
• W2063722263 countsByYear W20637222632016 @default.
• W2063722263 countsByYear W20637222632018 @default.
• W2063722263 countsByYear W20637222632019 @default.
• W2063722263 countsByYear W20637222632022 @default.
• W2063722263 crossrefType "journal-article" @default.
• W2063722263 hasAuthorship W2063722263A5001186893 @default.
• W2063722263 hasAuthorship W2063722263A5050446452 @default.
• W2063722263 hasAuthorship W2063722263A5051458827 @default.
• W2063722263 hasAuthorship W2063722263A5072415289 @default.
• W2063722263 hasAuthorship W2063722263A5084178973 @default.
• W2063722263 hasConcept C104317684 @default.
• W2063722263 hasConcept C126322002 @default.
• W2063722263 hasConcept C128240485 @default.
• W2063722263 hasConcept C134018914 @default.
• W2063722263 hasConcept C153911025 @default.
• W2063722263 hasConcept C164027704 @default.
• W2063722263 hasConcept C170493617 @default.
• W2063722263 hasConcept C203014093 @default.
• W2063722263 hasConcept C2776914184 @default.
• W2063722263 hasConcept C2777730290 @default.
• W2063722263 hasConcept C502942594 @default.
• W2063722263 hasConcept C54009773 @default.
• W2063722263 hasConcept C55493867 @default.
• W2063722263 hasConcept C71924100 @default.
• W2063722263 hasConcept C86803240 @default.
• W2063722263 hasConceptScore W2063722263C104317684 @default.
• W2063722263 hasConceptScore W2063722263C126322002 @default.
• W2063722263 hasConceptScore W2063722263C128240485 @default.
• W2063722263 hasConceptScore W2063722263C134018914 @default.
• W2063722263 hasConceptScore W2063722263C153911025 @default.
• W2063722263 hasConceptScore W2063722263C164027704 @default.
• W2063722263 hasConceptScore W2063722263C170493617 @default.
• W2063722263 hasConceptScore W2063722263C203014093 @default.
• W2063722263 hasConceptScore W2063722263C2776914184 @default.
• W2063722263 hasConceptScore W2063722263C2777730290 @default.
• W2063722263 hasConceptScore W2063722263C502942594 @default.
• W2063722263 hasConceptScore W2063722263C54009773 @default.
• W2063722263 hasConceptScore W2063722263C55493867 @default.
• W2063722263 hasConceptScore W2063722263C71924100 @default.

• next