FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063730880> ?p ?o ?g. }

• W2063730880 endingPage "450" @default.
• W2063730880 startingPage "439" @default.
• W2063730880 abstract "Plasminogen activator inhibitor 2 (PAI-2) is a serine protease inhibitor (serpin) that is secreted and accumulated intracellularly by monocytes. We investigated PAI-2 synthesis by isolated human peripheral blood monocytes and found that a 47-kDa nonglycosylated form of PAI-2 was abundant in conditioned medium from monocytes. Secretion of PAI-2 by monocytes was not inhibited by agents that inhibit either ER-Golgi pathway-dependent secretion, brefeldin A, or N-linked glycosylation, tunicamycin. IL-1beta served as a control for a protein that is secreted by an ER-Golgi-independent pathway, and secretion of IL-1beta was not inhibited by brefeldin A. This was in contrast to secretion of TNFalpha, which was dependent on the ER-Golgi pathway. None of the treatments was cytotoxic toward monocytes, as measured by release of the intracellular enzyme lactate dehydrogenase (LDH) into the conditioned medium. Subcellular fractionation revealed that PAI-2 and IL-1beta were colocalized. The mechanism for secretion of PAI-2 was not dependent on calcium or intracellular trafficking via the classical vesicular mechanism(s), distinguishing it from IL-1beta secretion. These studies show that PAI-2 is secreted by primary human monocytes via an ER-Golgi-independent pathway." @default.
• W2063730880 created "2016-06-24" @default.
• W2063730880 creator A5005108860 @default.
• W2063730880 creator A5025642740 @default.
• W2063730880 date "1998-08-01" @default.
• W2063730880 modified "2023-09-27" @default.
• W2063730880 title "Secretion of Plasminogen Activator Inhibitor 2 by Human Peripheral Blood Monocytes Occurs via an Endoplasmic Reticulum–Golgi-Independent Pathway" @default.
• W2063730880 cites W121387658 @default.
• W2063730880 cites W1481074036 @default.
• W2063730880 cites W1490634134 @default.
• W2063730880 cites W1533816737 @default.
• W2063730880 cites W1573267684 @default.
• W2063730880 cites W1595199664 @default.
• W2063730880 cites W1604280561 @default.
• W2063730880 cites W163282153 @default.
• W2063730880 cites W1638424324 @default.
• W2063730880 cites W1657916616 @default.
• W2063730880 cites W1667579103 @default.
• W2063730880 cites W1690904680 @default.
• W2063730880 cites W1771708403 @default.
• W2063730880 cites W1956379178 @default.
• W2063730880 cites W1967478221 @default.
• W2063730880 cites W1968810669 @default.
• W2063730880 cites W1971354637 @default.
• W2063730880 cites W1981570640 @default.
• W2063730880 cites W1983457890 @default.
• W2063730880 cites W1989839576 @default.
• W2063730880 cites W1991737551 @default.
• W2063730880 cites W1996263138 @default.
• W2063730880 cites W2004166313 @default.
• W2063730880 cites W2017708875 @default.
• W2063730880 cites W2020124431 @default.
• W2063730880 cites W2021245965 @default.
• W2063730880 cites W2023278573 @default.
• W2063730880 cites W2024576862 @default.
• W2063730880 cites W2035054080 @default.
• W2063730880 cites W2045532219 @default.
• W2063730880 cites W2057866531 @default.
• W2063730880 cites W2066758600 @default.
• W2063730880 cites W2075524572 @default.
• W2063730880 cites W2078001244 @default.
• W2063730880 cites W2092955550 @default.
• W2063730880 cites W2100863754 @default.
• W2063730880 cites W2116384616 @default.
• W2063730880 cites W2123663230 @default.
• W2063730880 cites W2139151974 @default.
• W2063730880 cites W2152025158 @default.
• W2063730880 cites W2162616877 @default.
• W2063730880 cites W2267935709 @default.
• W2063730880 cites W2278969192 @default.
• W2063730880 cites W2287013995 @default.
• W2063730880 cites W2411304768 @default.
• W2063730880 cites W2412703172 @default.
• W2063730880 cites W2413953398 @default.
• W2063730880 cites W2414274698 @default.
• W2063730880 cites W2414539133 @default.
• W2063730880 cites W2465495433 @default.
• W2063730880 doi "https://doi.org/10.1006/excr.1998.4118" @default.
• W2063730880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9683531" @default.
• W2063730880 hasPublicationYear "1998" @default.
• W2063730880 type Work @default.
• W2063730880 sameAs 2063730880 @default.
• W2063730880 citedByCount "38" @default.
• W2063730880 countsByYear W20637308802012 @default.
• W2063730880 countsByYear W20637308802013 @default.
• W2063730880 countsByYear W20637308802014 @default.
• W2063730880 countsByYear W20637308802019 @default.
• W2063730880 countsByYear W20637308802022 @default.
• W2063730880 countsByYear W20637308802023 @default.
• W2063730880 crossrefType "journal-article" @default.
• W2063730880 hasAuthorship W2063730880A5005108860 @default.
• W2063730880 hasAuthorship W2063730880A5025642740 @default.
• W2063730880 hasConcept C104317684 @default.
• W2063730880 hasConcept C119062480 @default.
• W2063730880 hasConcept C134018914 @default.
• W2063730880 hasConcept C139447449 @default.
• W2063730880 hasConcept C153911025 @default.
• W2063730880 hasConcept C156399914 @default.
• W2063730880 hasConcept C158617107 @default.
• W2063730880 hasConcept C181199279 @default.
• W2063730880 hasConcept C2776714187 @default.
• W2063730880 hasConcept C2777313579 @default.
• W2063730880 hasConcept C2777575526 @default.
• W2063730880 hasConcept C2777807008 @default.
• W2063730880 hasConcept C2778965386 @default.
• W2063730880 hasConcept C2779679481 @default.
• W2063730880 hasConcept C2780675426 @default.
• W2063730880 hasConcept C2781373781 @default.
• W2063730880 hasConcept C49039625 @default.
• W2063730880 hasConcept C55493867 @default.
• W2063730880 hasConcept C6492254 @default.
• W2063730880 hasConcept C86803240 @default.
• W2063730880 hasConcept C95444343 @default.
• W2063730880 hasConceptScore W2063730880C104317684 @default.
• W2063730880 hasConceptScore W2063730880C119062480 @default.
• W2063730880 hasConceptScore W2063730880C134018914 @default.
• W2063730880 hasConceptScore W2063730880C139447449 @default.
• W2063730880 hasConceptScore W2063730880C153911025 @default.

• next