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• W2063738419 abstract "CancerVolume 13, Issue 2 p. 236-240 ArticleFree Access Studies on the folic acid vitamins. IV. The persistence of amethopterin in mammalian tissues Samuel Charache M.D., Samuel Charache M.D. General Medicine Branch and the Laboratory of Chemical Pharmacology, National Cancer Institute, of the National Institutes of Health, Public Health Service, Bethesda, Md.Search for more papers by this authorPaul T. Condit M.D., PH.D., Paul T. Condit M.D., PH.D. General Medicine Branch and the Laboratory of Chemical Pharmacology, National Cancer Institute, of the National Institutes of Health, Public Health Service, Bethesda, Md.Search for more papers by this authorStewart R. Humphreys, Stewart R. Humphreys General Medicine Branch and the Laboratory of Chemical Pharmacology, National Cancer Institute, of the National Institutes of Health, Public Health Service, Bethesda, Md.Search for more papers by this author Samuel Charache M.D., Samuel Charache M.D. General Medicine Branch and the Laboratory of Chemical Pharmacology, National Cancer Institute, of the National Institutes of Health, Public Health Service, Bethesda, Md.Search for more papers by this authorPaul T. Condit M.D., PH.D., Paul T. Condit M.D., PH.D. General Medicine Branch and the Laboratory of Chemical Pharmacology, National Cancer Institute, of the National Institutes of Health, Public Health Service, Bethesda, Md.Search for more papers by this authorStewart R. Humphreys, Stewart R. Humphreys General Medicine Branch and the Laboratory of Chemical Pharmacology, National Cancer Institute, of the National Institutes of Health, Public Health Service, Bethesda, Md.Search for more papers by this author First published: March/April 1960 https://doi.org/10.1002/1097-0142(196003/04)13:2<236::AID-CNCR2820130205>3.0.CO;2-RCitations: 42AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1. Broquist, H. P., Stokstad, E. L. R., and Jukes, T. H.: Some biological and chemical properties of citrovorum factor. J. Biol. Chem. 185: 399– 409, 1950. 2. Charache, S., Condit, P. T., Levy, A. H., Humphreys, S. R., and Goldin, A.: Studies on folic acid vitamins; V, effect of folic acid on citrovorum factor activity of mouse liver. Cancer 13: 241– 244, 1960. 3. Cohen, J. A., and Warringa, M. G. P. J.: Fate of P32 labelled diisopropylfluorophosphonate in human body and its use as labelling agent in study of turnover of blood plasma and red cells. J. Clin. Invest. 33: 459– 467, 1954. 4. Condit, P. T.: Studies on folic acid vitamins; III, duration of effects of folic acid antagonists in man. Cancer 13: 229– 235, 1960. 5. Condit, P. T.: Unpublished data. 6. Fountain, J. R., Hutchison, D. J., Waring, G. B., and Burchenal, J. H.: Persistence of amethopterin in normal mouse tissues. Proc. Soc. Exper. Biol. & Med. 83: 369– 373, 1953. 7. Freeman, M. V.: Fluorometric measurement of absorption, distribution and excretion of single doses of 4-amino-10-methyl pteroylglutamic acid (amethopterin) in man. J. Pharmacol. & Exper. Therap. 122: 154– 162, 1958. 8. Goldin, A.: Employment of methods of inhibition analysis in normal and tumor-bearing mammalian organism. Advances Cancer Res. 4: 113– 148, 1956. 9. Greenspan, E. M., Goldin, A., and Schoenbach, E. B.: Studies on mechanism of action of chemotherapeutic agents in cancer; II, requirements for prevention of aminopterin toxicity by folic acid in mice. Cancer 3: 856– 863, 1950. 10. Greenspan, E. M., Goldin, A., and Schoenbach, E. B.: Studies on mechanism of action of chemotherapeutic agents in cancer; V, influence of citrovorum factor and folic acid on toxic manifestations of aminopterin in mice. Cancer 4: 619– 625, 1951. 11. Jandorf, B. J., and McN'amara, P. D.: Distribution of radiophosphorus in rabbit tissues after injection of phosphorus-labeled diisopropyl fluorophosphate. J. Pharm. & Exper. Therap. 98: 77– 84, 1950. 12. Mazur, A., and Bodansky, O.: Mechanism of in vitro and in vivo inhibition of cholinesterase activity by diisopropyl fluorophosphate. J. Biol. Chem. 163: 261– 276, 1946. 13. Michel, H. O., and Krop, S.: Reaction of cholinesterase with diisopropyl fluorophosphate. J. Biol. Chem. 190: 119– 125, 1951. 14. Swenseif, M. E., Swanson, A. L., Miller, S. and Bethell, F. H.: Metabolic displacement of folic acid by aminopterin; studies in leukemia patients. Blood 7: 302– 306, 1952. 15. Werkheiser, W. C.: Specificity of enzyme binding by A-methopterin and aminopterin in vivo and in vitro. Proc. Am. A. Cancer Res. 3: 72– 73, 1959. 16. Zakrzewski, S. F., and Nichol, C. A.: Separation and determination of pteroylglutamic acid and related compounds. J. Biol. Chem. 205: 361– 368, 1953. Citing Literature Volume13, Issue2March/April 1960Pages 236-240 ReferencesRelatedInformation" @default.
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