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• W2063742306 abstract "Selection of an extragenic suppressor of fks1-1154 Δfks2, mutations in the catalytic subunits of yeast 1,3-β-glucan synthase (GS) conferring temperature-sensitivity, led to the LRG1 gene, which was originally identified as a LIM-RhoGAP homologous gene. Mutations in the LRG1 gene restore impaired 1,3-β-glucan synthesis in the fks1-1154 Δfks2 mutant as well as that in rho1-2, a temperature-sensitive mutant of Rho-type GTPase that functions as a regulatory subunit of GS. Two-hybrid analyses of Lrg1p, which contains a sequence conserved among Rho GTPase-activating proteins (GAPs), revealed its specific interactions with the active form of Rho1p. Among eight potential yeast RhoGAPs, Lrg1p is the only member that negatively regulates GS activity: mutations in the rest of GAPs, including bem2, Δbem3, Δsac7, Δbag7, Δrga1, Δrga2 and Δrgd1, do not suppress impairment of 1,3-β-glucan synthesis. Analyses of Mpk1p phosphorylation revealed the inability of Lrg1p to regulate the Pkc1p–MAP kinase cascade, a distinct Rho1p-regulating signalling pathway known to be affected by the GAPs, Bem2p and Sac7p. Thus, different groups of Rho1p GAPs control the activity of different Rho1p-effector proteins. Copyright © 2001 John Wiley & Sons, Ltd." @default.
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• W2063742306 date "2001-01-01" @default.
• W2063742306 modified "2023-10-03" @default.
• W2063742306 title "Yeast Lrg1p acts as a specialized RhoGAP regulating 1,3-?-glucan synthesis" @default.
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• W2063742306 doi "https://doi.org/10.1002/yea.742" @default.
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