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- W2063745641 abstract "WE studied the effects of granulocyte-macrophage colony stimulating factor (GM-CSF) on the brain levels of several neurotransmitters in mice. Administration of GM-CSF (5.0 and 10 μg, i.p.) significantly reduced the hypothalamic levels of glutamine, glutamic acid, GABA and aspartic acid. GM-CSF (5.0 μg, i.p.) also induced a significant reduction of norepinephrine and serotonin levels in the hypothalamus, without affecting dopamine levels. The hippocampal levels of neurotransmitters were not modified by GM-CSF administration. The peripheral administration of a specific interleukin-1 receptor antagonist (IL-1ra, 50 μg, i.p.) blocked the effects of GM-CSF. These results confirm our previous behavioural data suggesting that GM-CSF is able to exert neuromodulatory actions." @default.
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- W2063745641 date "1997-11-01" @default.
- W2063745641 modified "2023-09-27" @default.
- W2063745641 title "GM-CSF affects hypothalamic neurotransmitter levels in mice" @default.
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- W2063745641 doi "https://doi.org/10.1097/00001756-199711100-00033" @default.
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