FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063749501> ?p ?o ?g. }

• W2063749501 endingPage "1359" @default.
• W2063749501 startingPage "1353" @default.
• W2063749501 abstract "The placental-umbilical unit in sickle cell disease (SCD) pregnancy was used to explore hypoxia in vivo, an important factor in the pathophysiology of this disease. Gross examination and microscopic analysis of the placentas, taken immediately after delivery, indicate good concordance between maturity and term as controls, but higher frequency of vascular injuries such as excess syncytial knots, excess fibrin deposits, congestion and villous necroses. Unexpectedly, neither leukocyte recruitment nor alteration in extraplacental membrane was observed, suggesting the absence of inflammation. Additionally, interleukin (IL)-6 and IL-8 concentrations, measured by enzyme-linked immunosorbent assay (ELISA), were similar in the placental maternal blood from controls and SCD. There were also no significant differences found in IL-6 vein blood concentrations between controls and SCD, IL-8 being not detected. Immunostaining of umbilical vein endothelium in SCD pregnancies showed redistribution of PECAM-1 (CD31), von Willebrand factor (vWF), and P-selectin to the cell surface, controls exhibiting the classical pattern. Staining quantification indicated increases in vWF (+36.2%; P = .006) and vascular endothelial growth factor (VEGF) expression (+96.0%; P = .006) over control, but a reduction in endothelial nitric oxide synthase (eNOS) (−45.5%; P = .029). These results document, for the first time, direct functional adjustments in response to hypoxia in human in vivo. The mechanism for these changes has not been clearly established, but it may reflect increased tolerance to SCD hypoxic conditions and hypoxia in general." @default.
• W2063749501 created "2016-06-24" @default.
• W2063749501 creator A5009789806 @default.
• W2063749501 creator A5011791357 @default.
• W2063749501 creator A5011842364 @default.
• W2063749501 creator A5016551987 @default.
• W2063749501 creator A5030897241 @default.
• W2063749501 creator A5035364268 @default.
• W2063749501 creator A5036769669 @default.
• W2063749501 creator A5041126135 @default.
• W2063749501 creator A5054394912 @default.
• W2063749501 creator A5062693473 @default.
• W2063749501 creator A5072415317 @default.
• W2063749501 date "2004-11-01" @default.
• W2063749501 modified "2023-10-10" @default.
• W2063749501 title "The placental-umbilical unit in sickle cell disease pregnancy: A model for studying in vivo functional adjustments to hypoxia in humans" @default.
• W2063749501 cites W15592170 @default.
• W2063749501 cites W1982687474 @default.
• W2063749501 cites W1992431516 @default.
• W2063749501 cites W1992666197 @default.
• W2063749501 cites W2009947833 @default.
• W2063749501 cites W2014907034 @default.
• W2063749501 cites W2027816595 @default.
• W2063749501 cites W2049421390 @default.
• W2063749501 cites W2050636488 @default.
• W2063749501 cites W2057363881 @default.
• W2063749501 cites W2063172447 @default.
• W2063749501 cites W2063646489 @default.
• W2063749501 cites W2064864749 @default.
• W2063749501 cites W2067738744 @default.
• W2063749501 cites W2068918480 @default.
• W2063749501 cites W2072845754 @default.
• W2063749501 cites W2083399493 @default.
• W2063749501 cites W2104732966 @default.
• W2063749501 cites W2108225039 @default.
• W2063749501 cites W2114086946 @default.
• W2063749501 cites W2114087215 @default.
• W2063749501 cites W2164487251 @default.
• W2063749501 cites W2194318279 @default.
• W2063749501 cites W2249805131 @default.
• W2063749501 cites W2345881861 @default.
• W2063749501 cites W2369812396 @default.
• W2063749501 cites W2464601134 @default.
• W2063749501 cites W27650594 @default.
• W2063749501 cites W4237563548 @default.
• W2063749501 cites W4240800534 @default.
• W2063749501 cites W4246055356 @default.
• W2063749501 doi "https://doi.org/10.1016/j.humpath.2004.07.003" @default.
• W2063749501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15668892" @default.
• W2063749501 hasPublicationYear "2004" @default.
• W2063749501 type Work @default.
• W2063749501 sameAs 2063749501 @default.
• W2063749501 citedByCount "24" @default.
• W2063749501 countsByYear W20637495012012 @default.
• W2063749501 countsByYear W20637495012013 @default.
• W2063749501 countsByYear W20637495012015 @default.
• W2063749501 countsByYear W20637495012016 @default.
• W2063749501 countsByYear W20637495012018 @default.
• W2063749501 countsByYear W20637495012019 @default.
• W2063749501 countsByYear W20637495012020 @default.
• W2063749501 countsByYear W20637495012021 @default.
• W2063749501 countsByYear W20637495012022 @default.
• W2063749501 crossrefType "journal-article" @default.
• W2063749501 hasAuthorship W2063749501A5009789806 @default.
• W2063749501 hasAuthorship W2063749501A5011791357 @default.
• W2063749501 hasAuthorship W2063749501A5011842364 @default.
• W2063749501 hasAuthorship W2063749501A5016551987 @default.
• W2063749501 hasAuthorship W2063749501A5030897241 @default.
• W2063749501 hasAuthorship W2063749501A5035364268 @default.
• W2063749501 hasAuthorship W2063749501A5036769669 @default.
• W2063749501 hasAuthorship W2063749501A5041126135 @default.
• W2063749501 hasAuthorship W2063749501A5054394912 @default.
• W2063749501 hasAuthorship W2063749501A5062693473 @default.
• W2063749501 hasAuthorship W2063749501A5072415317 @default.
• W2063749501 hasConcept C104317684 @default.
• W2063749501 hasConcept C126322002 @default.
• W2063749501 hasConcept C134018914 @default.
• W2063749501 hasConcept C150903083 @default.
• W2063749501 hasConcept C160450060 @default.
• W2063749501 hasConcept C16685009 @default.
• W2063749501 hasConcept C172680121 @default.
• W2063749501 hasConcept C178790620 @default.
• W2063749501 hasConcept C185592680 @default.
• W2063749501 hasConcept C202751555 @default.
• W2063749501 hasConcept C203014093 @default.
• W2063749501 hasConcept C207001950 @default.
• W2063749501 hasConcept C2776317666 @default.
• W2063749501 hasConcept C2776953305 @default.
• W2063749501 hasConcept C2776992346 @default.
• W2063749501 hasConcept C2777411675 @default.
• W2063749501 hasConcept C2778939058 @default.
• W2063749501 hasConcept C2779234561 @default.
• W2063749501 hasConcept C2779394231 @default.
• W2063749501 hasConcept C2780394083 @default.
• W2063749501 hasConcept C540031477 @default.
• W2063749501 hasConcept C54355233 @default.
• W2063749501 hasConcept C55493867 @default.
• W2063749501 hasConcept C71924100 @default.

• next