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- W2063749843 abstract "Platinum-based doublets are a standard for treatment of advanced non–small-cell lung cancer (NSCLC). Docetaxel has shown good single-agent activity in advanced NSCLC, with response rates of 20%-38% with a 100 mg/m2 dose.1,2 The combination of docetaxel with platinum agents (carboplatin and cisplatin) has shown high efficacy in chemotherapy-naive patients with advanced NSCLC, with response rates in phase II trials ranging from 21%-48%. Table 1 summarizes some of these studies.3-8 To further evaluate both docetaxel/cisplatin and docetaxel/carboplatin in advanced NSCLC, a randomized trial was conducted to directly compare these two regimens with the control arm of vinorelbine/cisplatin in previously untreated patients with advanced NSCLC. The results of this study were presented at the 2001 American Society of Clinical Oncology (ASCO) Meeting held in San Francisco and are summarized below.9 This phase III trial was a randomized multicenter study, which included adult patients with histologically or cytologically confirmed stage IIIB/IV NSCLC. Patients were required to have measurable disease; a Karnofsky performance status (KPS) ≥ 70%; adequate hepatic, bone marrow, and renal function; and no peripheral neuropathy greater than grade 2. No prior biologic therapy or chemotherapy was allowed. One thousand twelve hundred twenty" @default.
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- W2063749843 date "2001-08-01" @default.
- W2063749843 modified "2023-10-14" @default.
- W2063749843 title "2001 Highlights From: 37th Annual American Society of Clinical Oncology Meeting San Francisco, CA May 12–15, 2001" @default.
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- W2063749843 doi "https://doi.org/10.1016/s1525-7304(11)70745-8" @default.
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