Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063760505> ?p ?o ?g. }
- W2063760505 endingPage "e52367" @default.
- W2063760505 startingPage "e52367" @default.
- W2063760505 abstract "Epidemiological case-control studies have revealed associations between mitochondrial haplogroups and the onset and/or progression of various multifactorial diseases. For instance, mitochondrial haplogroup T was previously shown to be associated with vascular diseases, including coronary artery disease and diabetic retinopathy. In contrast, haplogroup H, the most frequent haplogroup in Europe, is often found to be more prevalent in healthy control subjects than in patient study groups. However, justifications for the assumption that haplogroups are functionally distinct are rare. Therefore, we attempted to compare differences in mitochondrial function between haplogroup H and T cybrids.Mitochondrial haplogroup H and T cybrids were generated by fusion of HEK293 cells devoid of mitochondrial DNA with isolated thrombocytes of individuals with the respective haplogroups. These cybrid cells were analyzed for oxidative phosphorylation (OXPHOS) enzyme activities, mitochondrial DNA (mtDNA) copy number, growth rate and susceptibility to reactive oxygen species (ROS). We observed that haplogroup T cybrids have higher survival rate when challenged with hydrogen peroxide, indicating a higher capability to cope with oxidative stress.The results of this study show that functional differences exist between HEK293 cybrid cells which differ in mitochondrial genomic background." @default.
- W2063760505 created "2016-06-24" @default.
- W2063760505 creator A5012173616 @default.
- W2063760505 creator A5021299048 @default.
- W2063760505 creator A5027522449 @default.
- W2063760505 creator A5047589847 @default.
- W2063760505 creator A5059829670 @default.
- W2063760505 creator A5061366659 @default.
- W2063760505 date "2012-12-26" @default.
- W2063760505 modified "2023-10-16" @default.
- W2063760505 title "Functional Differences between Mitochondrial Haplogroup T and Haplogroup H in HEK293 Cybrid Cells" @default.
- W2063760505 cites W1629240889 @default.
- W2063760505 cites W1903135385 @default.
- W2063760505 cites W1964637189 @default.
- W2063760505 cites W1965817281 @default.
- W2063760505 cites W1966828661 @default.
- W2063760505 cites W1968516838 @default.
- W2063760505 cites W1976102972 @default.
- W2063760505 cites W1985469310 @default.
- W2063760505 cites W1989669460 @default.
- W2063760505 cites W1991257449 @default.
- W2063760505 cites W1992664890 @default.
- W2063760505 cites W1996923449 @default.
- W2063760505 cites W1997640580 @default.
- W2063760505 cites W1998717100 @default.
- W2063760505 cites W2005758857 @default.
- W2063760505 cites W2007790334 @default.
- W2063760505 cites W2009756075 @default.
- W2063760505 cites W2012645980 @default.
- W2063760505 cites W2012729515 @default.
- W2063760505 cites W2017213538 @default.
- W2063760505 cites W2019541219 @default.
- W2063760505 cites W2027498679 @default.
- W2063760505 cites W2030227512 @default.
- W2063760505 cites W2037915591 @default.
- W2063760505 cites W2038511818 @default.
- W2063760505 cites W2040979033 @default.
- W2063760505 cites W2042616867 @default.
- W2063760505 cites W2044453355 @default.
- W2063760505 cites W2044494908 @default.
- W2063760505 cites W2056852384 @default.
- W2063760505 cites W2061104433 @default.
- W2063760505 cites W2062957434 @default.
- W2063760505 cites W2069057403 @default.
- W2063760505 cites W2072056861 @default.
- W2063760505 cites W2072451938 @default.
- W2063760505 cites W2072715712 @default.
- W2063760505 cites W2103939468 @default.
- W2063760505 cites W2105754268 @default.
- W2063760505 cites W2117991561 @default.
- W2063760505 cites W2119627167 @default.
- W2063760505 cites W2122232395 @default.
- W2063760505 cites W2123319125 @default.
- W2063760505 cites W2133367167 @default.
- W2063760505 cites W2139699261 @default.
- W2063760505 cites W2141830410 @default.
- W2063760505 cites W2141847223 @default.
- W2063760505 cites W2141910024 @default.
- W2063760505 cites W2145882912 @default.
- W2063760505 cites W2147628814 @default.
- W2063760505 cites W2154385453 @default.
- W2063760505 cites W2164277750 @default.
- W2063760505 cites W2166664098 @default.
- W2063760505 cites W2167480986 @default.
- W2063760505 cites W4302545197 @default.
- W2063760505 doi "https://doi.org/10.1371/journal.pone.0052367" @default.
- W2063760505 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3530588" @default.
- W2063760505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23300652" @default.
- W2063760505 hasPublicationYear "2012" @default.
- W2063760505 type Work @default.
- W2063760505 sameAs 2063760505 @default.
- W2063760505 citedByCount "51" @default.
- W2063760505 countsByYear W20637605052013 @default.
- W2063760505 countsByYear W20637605052014 @default.
- W2063760505 countsByYear W20637605052015 @default.
- W2063760505 countsByYear W20637605052016 @default.
- W2063760505 countsByYear W20637605052017 @default.
- W2063760505 countsByYear W20637605052018 @default.
- W2063760505 countsByYear W20637605052019 @default.
- W2063760505 countsByYear W20637605052020 @default.
- W2063760505 countsByYear W20637605052021 @default.
- W2063760505 countsByYear W20637605052022 @default.
- W2063760505 countsByYear W20637605052023 @default.
- W2063760505 crossrefType "journal-article" @default.
- W2063760505 hasAuthorship W2063760505A5012173616 @default.
- W2063760505 hasAuthorship W2063760505A5021299048 @default.
- W2063760505 hasAuthorship W2063760505A5027522449 @default.
- W2063760505 hasAuthorship W2063760505A5047589847 @default.
- W2063760505 hasAuthorship W2063760505A5059829670 @default.
- W2063760505 hasAuthorship W2063760505A5061366659 @default.
- W2063760505 hasBestOaLocation W20637605051 @default.
- W2063760505 hasConcept C104317684 @default.
- W2063760505 hasConcept C153911025 @default.
- W2063760505 hasConcept C180754005 @default.
- W2063760505 hasConcept C197754878 @default.
- W2063760505 hasConcept C201526758 @default.
- W2063760505 hasConcept C24586158 @default.
- W2063760505 hasConcept C28859421 @default.