FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063764609> ?p ?o ?g. }

• W2063764609 endingPage "65" @default.
• W2063764609 startingPage "57" @default.
• W2063764609 abstract "The breast/ovarian cancer susceptibility gene BRCA1 interact with multiple protein complexes involved in cellular mechanisms, such as DNA repair, transcription, homologous recombination and cell cycle regulation. Extensive analyses over the past decade led to the detection of several BRCA1 alternative splice variants. Here, we identify the first BRCA1 alternative splice variant containing an additional in-frame exon. This previously unknown exon 13A-containing transcript is generated by the insertion of 66 nucleotides between exons 13 and 14, due to alternative splicing in intron 13 (IVS13-2786-2720). Furthermore, exon 13A-containing transcript was detectable in total RNA samples from 12 normal tissues and several breast and other cancer cell lines. As revealed by real-time PCR analysis, this transcript corresponds to 20 to 25% of the total BRCA1 mRNA expression levels in leukocytes, brain and cerebellum tissues, whereas its relative level of expression is less than 5% in other tested tissues and cancer cell lines. This novel alternative transcript adds 22 amino acids after residue 1452, thus modifying the primary structure of the trans-activation domain 1 (AD1) and the protein-protein interacting domain of BRCA1 with BRCA2, AR and MSH2. No sequence variant has been detected by direct genomic sequencing of exon 13A in individuals originating from high-risk breast/ovarian cancer families." @default.
• W2063764609 created "2016-06-24" @default.
• W2063764609 creator A5009535585 @default.
• W2063764609 creator A5016920717 @default.
• W2063764609 creator A5023628228 @default.
• W2063764609 creator A5027909964 @default.
• W2063764609 creator A5034622521 @default.
• W2063764609 creator A5042154332 @default.
• W2063764609 creator A5045762949 @default.
• W2063764609 creator A5049881048 @default.
• W2063764609 creator A5057180286 @default.
• W2063764609 creator A5058111076 @default.
• W2063764609 creator A5058755438 @default.
• W2063764609 creator A5058944149 @default.
• W2063764609 creator A5065425251 @default.
• W2063764609 creator A5068835638 @default.
• W2063764609 creator A5079867815 @default.
• W2063764609 creator A5087341200 @default.
• W2063764609 creator A5090543669 @default.
• W2063764609 date "2005-10-01" @default.
• W2063764609 modified "2023-09-27" @default.
• W2063764609 title "A new alternative splice variant of BRCA1 containing an additional in-frame exon" @default.
• W2063764609 cites W1487538033 @default.
• W2063764609 cites W1963793607 @default.
• W2063764609 cites W1965748552 @default.
• W2063764609 cites W1971255279 @default.
• W2063764609 cites W1972152765 @default.
• W2063764609 cites W1972710550 @default.
• W2063764609 cites W1977967386 @default.
• W2063764609 cites W1983954245 @default.
• W2063764609 cites W1985519257 @default.
• W2063764609 cites W1991841649 @default.
• W2063764609 cites W2003060921 @default.
• W2063764609 cites W2004297363 @default.
• W2063764609 cites W2005284058 @default.
• W2063764609 cites W2006152718 @default.
• W2063764609 cites W2007558412 @default.
• W2063764609 cites W2011094690 @default.
• W2063764609 cites W2011658104 @default.
• W2063764609 cites W2015087800 @default.
• W2063764609 cites W2025370752 @default.
• W2063764609 cites W2027376329 @default.
• W2063764609 cites W2029784730 @default.
• W2063764609 cites W2030093162 @default.
• W2063764609 cites W2034317592 @default.
• W2063764609 cites W2038984476 @default.
• W2063764609 cites W2044336345 @default.
• W2063764609 cites W2048619264 @default.
• W2063764609 cites W2050376635 @default.
• W2063764609 cites W2051184323 @default.
• W2063764609 cites W2054605948 @default.
• W2063764609 cites W2057949133 @default.
• W2063764609 cites W2066969492 @default.
• W2063764609 cites W2082062095 @default.
• W2063764609 cites W2083814146 @default.
• W2063764609 cites W2084841290 @default.
• W2063764609 cites W2103195302 @default.
• W2063764609 cites W2103533058 @default.
• W2063764609 cites W2109173575 @default.
• W2063764609 cites W2109465247 @default.
• W2063764609 cites W2112982595 @default.
• W2063764609 cites W2115149771 @default.
• W2063764609 cites W2118498634 @default.
• W2063764609 cites W2124371549 @default.
• W2063764609 cites W2128761168 @default.
• W2063764609 cites W2134303868 @default.
• W2063764609 cites W2139372524 @default.
• W2063764609 cites W2143464311 @default.
• W2063764609 cites W2144031018 @default.
• W2063764609 cites W2148901907 @default.
• W2063764609 cites W2149827592 @default.
• W2063764609 cites W2153973987 @default.
• W2063764609 cites W2156924110 @default.
• W2063764609 cites W2157052459 @default.
• W2063764609 cites W2164916497 @default.
• W2063764609 cites W2165922492 @default.
• W2063764609 cites W2168718259 @default.
• W2063764609 cites W2169817991 @default.
• W2063764609 cites W4247292500 @default.
• W2063764609 cites W4300265477 @default.
• W2063764609 doi "https://doi.org/10.1016/j.bbaexp.2005.08.011" @default.
• W2063764609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16185777" @default.
• W2063764609 hasPublicationYear "2005" @default.
• W2063764609 type Work @default.
• W2063764609 sameAs 2063764609 @default.
• W2063764609 citedByCount "18" @default.
• W2063764609 countsByYear W20637646092013 @default.
• W2063764609 countsByYear W20637646092014 @default.
• W2063764609 countsByYear W20637646092019 @default.
• W2063764609 crossrefType "journal-article" @default.
• W2063764609 hasAuthorship W2063764609A5009535585 @default.
• W2063764609 hasAuthorship W2063764609A5016920717 @default.
• W2063764609 hasAuthorship W2063764609A5023628228 @default.
• W2063764609 hasAuthorship W2063764609A5027909964 @default.
• W2063764609 hasAuthorship W2063764609A5034622521 @default.
• W2063764609 hasAuthorship W2063764609A5042154332 @default.
• W2063764609 hasAuthorship W2063764609A5045762949 @default.
• W2063764609 hasAuthorship W2063764609A5049881048 @default.

• next