Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063770908> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2063770908 endingPage "338" @default.
- W2063770908 startingPage "331" @default.
- W2063770908 abstract "Phenytoin (PHT) exhibits nonlinear pharmacokinetics in the therapeutic range. Therefore a slight increase in dose may lead to considerable elevation of the serum PHT level. Although its bioavailability is dependent on the formulation, bioequivalence is considered to be preserved between the three major formulations, of tablet, 97% fine granules, and 10% powder. However, we experienced many cases of increases serum PHT concentration after changes in formulation from 97% fine granules to 97/4% hospital-made fine granules, and from the latter to 10% powder. Retrospective analysis revealed that these alterations were accompanied by 55% and 16% increases in the serum concentration-to-dose ratio of PHT, respectively. We investigated the factors of this increase by analyzing the weight of remaining powder in a package and the PHT content of each formulation. Each package of PHT formulation prepared with 97% fine granules and 10% powder was unsealed, and the contents were weighed to calculate the rate of recovery. The rate of ingestion was estimated by correcting the rate of recovery by PHT strength (i.e., 1.0 for 10% powder and 0.97 for fine granules). The rates of recovery and ingestion for 10% powder were 13% and 16% higher than those for 97% fine granules, respectively (p < 0.01). In conclusion, Changing the PHT formulation from 97% fine granules to 10% powder may lead to a considerable increase in the serum PHT concentration and possibly induce PHT toxicity." @default.
- W2063770908 created "2016-06-24" @default.
- W2063770908 creator A5004089873 @default.
- W2063770908 creator A5043481416 @default.
- W2063770908 creator A5046902025 @default.
- W2063770908 creator A5079742854 @default.
- W2063770908 creator A5084776993 @default.
- W2063770908 date "2002-05-01" @default.
- W2063770908 modified "2023-10-18" @default.
- W2063770908 title "An Increase in Serum Phenytoin Concentration by Changes of Dosage Form: Case Reports and Its Mechanism" @default.
- W2063770908 cites W1866645300 @default.
- W2063770908 cites W1966684763 @default.
- W2063770908 cites W1998149903 @default.
- W2063770908 cites W2093386232 @default.
- W2063770908 cites W2131933646 @default.
- W2063770908 doi "https://doi.org/10.1248/yakushi.122.331" @default.
- W2063770908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12040752" @default.
- W2063770908 hasPublicationYear "2002" @default.
- W2063770908 type Work @default.
- W2063770908 sameAs 2063770908 @default.
- W2063770908 citedByCount "0" @default.
- W2063770908 crossrefType "journal-article" @default.
- W2063770908 hasAuthorship W2063770908A5004089873 @default.
- W2063770908 hasAuthorship W2063770908A5043481416 @default.
- W2063770908 hasAuthorship W2063770908A5046902025 @default.
- W2063770908 hasAuthorship W2063770908A5079742854 @default.
- W2063770908 hasAuthorship W2063770908A5084776993 @default.
- W2063770908 hasBestOaLocation W20637709081 @default.
- W2063770908 hasConcept C112705442 @default.
- W2063770908 hasConcept C118552586 @default.
- W2063770908 hasConcept C126322002 @default.
- W2063770908 hasConcept C181389837 @default.
- W2063770908 hasConcept C185592680 @default.
- W2063770908 hasConcept C193230392 @default.
- W2063770908 hasConcept C2778186239 @default.
- W2063770908 hasConcept C2778337148 @default.
- W2063770908 hasConcept C3020081911 @default.
- W2063770908 hasConcept C42404028 @default.
- W2063770908 hasConcept C43617362 @default.
- W2063770908 hasConcept C55493867 @default.
- W2063770908 hasConcept C71924100 @default.
- W2063770908 hasConcept C77281830 @default.
- W2063770908 hasConcept C98274493 @default.
- W2063770908 hasConceptScore W2063770908C112705442 @default.
- W2063770908 hasConceptScore W2063770908C118552586 @default.
- W2063770908 hasConceptScore W2063770908C126322002 @default.
- W2063770908 hasConceptScore W2063770908C181389837 @default.
- W2063770908 hasConceptScore W2063770908C185592680 @default.
- W2063770908 hasConceptScore W2063770908C193230392 @default.
- W2063770908 hasConceptScore W2063770908C2778186239 @default.
- W2063770908 hasConceptScore W2063770908C2778337148 @default.
- W2063770908 hasConceptScore W2063770908C3020081911 @default.
- W2063770908 hasConceptScore W2063770908C42404028 @default.
- W2063770908 hasConceptScore W2063770908C43617362 @default.
- W2063770908 hasConceptScore W2063770908C55493867 @default.
- W2063770908 hasConceptScore W2063770908C71924100 @default.
- W2063770908 hasConceptScore W2063770908C77281830 @default.
- W2063770908 hasConceptScore W2063770908C98274493 @default.
- W2063770908 hasIssue "5" @default.
- W2063770908 hasLocation W20637709081 @default.
- W2063770908 hasLocation W20637709082 @default.
- W2063770908 hasOpenAccess W2063770908 @default.
- W2063770908 hasPrimaryLocation W20637709081 @default.
- W2063770908 hasRelatedWork W1984498366 @default.
- W2063770908 hasRelatedWork W2017999632 @default.
- W2063770908 hasRelatedWork W2080955156 @default.
- W2063770908 hasRelatedWork W2169439801 @default.
- W2063770908 hasRelatedWork W2354680669 @default.
- W2063770908 hasRelatedWork W2359939078 @default.
- W2063770908 hasRelatedWork W2369726129 @default.
- W2063770908 hasRelatedWork W2377576316 @default.
- W2063770908 hasRelatedWork W2402389484 @default.
- W2063770908 hasRelatedWork W3204382284 @default.
- W2063770908 hasVolume "122" @default.
- W2063770908 isParatext "false" @default.
- W2063770908 isRetracted "false" @default.
- W2063770908 magId "2063770908" @default.
- W2063770908 workType "article" @default.